{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:54Z","timestamp":1786978194285,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Crimean Congo hemorrhagic fever (CCHF) is an acute viral infection that can cause death. The detection of host transcriptome is important for understanding differences in the pathogenesis of the disease. Long noncoding RNAs (lncRNAs) regulate gene expression in different biological processes. They have also emerged as key molecules for therapeutic targets. We investigated the lncRNA gene expression profiles by utilizing the microarray for the first time in CCHF. LncRNAs were determined by the comparisons between case\u2010control, fatal case\u2010control, and fatal case\u2010nonfatal cases. Quantitative polymerase chain reaction\u00a0was applied to validate the microarray results of some lncRNAs. In our study, 39 lncRNAs (5 downregulated\u00a0and 34 upregulated) were found to be significantly regulated in the cases when compared to the controls (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05; FC\u2009\u2265\u20092). One hundred ten lncRNAs exhibited a statistically significant difference between fatal cases and controls. FER1L4, ECRP, and LOC100133669 are important lncRNAs in both case and fatal case groups compared with controls. These lncRNAs may be considered important therapeutic targets for the CCHF in further studies.\n                  <\/jats:p>","DOI":"10.1002\/jmv.27721","type":"journal-article","created":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T22:18:47Z","timestamp":1647209927000},"page":"3257-3262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long noncoding RNA expression analysis in Crimean Congo hemorrhagic fever patients"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3921-8061","authenticated-orcid":false,"given":"Serdal","family":"Arslan","sequence":"first","affiliation":[{"name":"Department of Medical Biology, Faculty of Medicine Mersin University  Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Bakir","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine Sivas Cumhuriyet University  Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5618-457X","authenticated-orcid":false,"given":"Burcu","family":"Bayyurt","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Faculty of Medicine Sivas Cumhuriyet University  Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eylem I.","family":"Aydemir","sequence":"additional","affiliation":[{"name":"Department of Statistic, Faculty of Science Sivas Cumhuriyet University  Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenan","family":"Kinaci","sequence":"additional","affiliation":[{"name":"SEM Laboratories  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aynur","family":"Engin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine Sivas Cumhuriyet 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