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Overall, 398 (76%) were males and 30 (6%) were diagnosed with AIDS. In the pre\u2010GRT group, baseline CD4+\u2009cell counts were lower (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and viral load was higher (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) than in the post\u2010GRT group. The estimated probability of VS in pre\u2010GRT versus post\u2010GRT group was 72.54% (CI\n                    <jats:sub>95<\/jats:sub>\n                    : 67.78\u201376.60) versus 66.94% (CI\n                    <jats:sub>95<\/jats:sub>\n                    : 57.53\u201374.26) at Week 24\u00a0and 92.40% (CI\n                    <jats:sub>95<\/jats:sub>\n                    : 89.26\u201394.62) versus 92.92% (CI\n                    <jats:sub>95<\/jats:sub>\n                    : 86.35\u201396.33) at Week 48, respectively (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.434). At Week 48, VS was less frequent among individuals with baseline CD4+\u2009cell counts &lt;200 versus &gt;500 (90.33% vs. 97.33%), log viral load &lt;5.00\u00a0versus &gt;5.70 log\n                    <jats:sub>10<\/jats:sub>\n                    cps\/ml (97.17% vs 78.16%;\u00a0\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and those treated with protease inhibitors or non\u2010nucleoside reverse transcriptase inhibitors versus those treated with integrase strand transfer inhibitors (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001).\u00a0The rate of VS does not seem to be affected by an early ART initiation pending GRT results, but it could be influenced by the composition of the ART regimen, as well as immuno\u2010virological parameters.\n                  <\/jats:p>","DOI":"10.1002\/jmv.27754","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T04:19:41Z","timestamp":1648700381000},"page":"3890-3899","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Early versus delayed antiretroviral therapy based on genotypic resistance test: Results from a large retrospective cohort study"],"prefix":"10.1002","volume":"94","author":[{"given":"Davide F.","family":"Bavaro","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology, Clinic of Infectious Diseases University of Bari Aldo Moro Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"De Vito","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Department of Medical, Surgical and Experimental Sciences University of Sassari Sassari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0499-2292","authenticated-orcid":false,"given":"Giuseppe","family":"Pasculli","sequence":"additional","affiliation":[{"name":"Department of Computer,\u00a0Control and Management Engineering Antonio Ruberti (DIAG) La Sapienza University Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yagai","family":"Bouba","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine University of Rome \u201cTor Vergata\u201d Rome Italy"},{"name":"Chantal BIYA International Reference Centre for Research on HIV\/AIDS Prevention and Management (CIRCB) Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Magnasco","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit Ospedale Policlinico San Martino \u2013 IRCCS per l'Oncologia Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachele","family":"Pincino","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit Ospedale Policlinico San Martino \u2013 IRCCS per l'Oncologia Genoa Italy"},{"name":"Department of Health Sciences University of Genoa Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Saladini","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies University of Siena Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossana","family":"Lattanzio","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology, Clinic of Infectious Diseases University of Bari Aldo Moro Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romina","family":"Corsini","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit AUSL \u2010 IRCCS Reggio Emilia Reggio Emilia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Arima","sequence":"additional","affiliation":[{"name":"Department of History,\u00a0Society and Human Studies University of Salento Lecce Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Zazzi","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies University of Siena Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Incardona","sequence":"additional","affiliation":[{"name":"InformaPRO s.r.l. 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