{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T14:04:35Z","timestamp":1771250675497,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:00:00Z","timestamp":1650326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:00:00Z","timestamp":1650326400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The Delta variant has gradually replaced the Alpha variant as the major strain of SARS\u2010COV\u20102 infection worldwide.\u00a0We extracted the clinical characteristics and outcomes information about 381 hospitalized patients infected with Delta variant and compared them with 856 patients diagnosed with Alpha variant infection in Zhejiang Province.\u00a0The majority (85.3%) of patients infected with the Delta variant had received inactivated vaccine. The patients' condition was generally mild. Most of them were mild (35.7%) and common (62.7%) types. Only six patients (1.5%) were severe\/critical types. During the follow\u2010up period, patients infected with the Delta variant had longer hospital stays than the Alpha variant (24 [21\u201326] vs. 18 [14\u201324],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). In addition, the unvaccinated patients infected with the Delta variant had a higher proportion of severe\/critical cases than vaccinated patients (11.11% vs. 0.92%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.024) and a higher usage rate of glucocorticoids (38.89 vs. 14.77%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.017) and antibiotics (55.56% vs. 32.31%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.042) during hospitalization. The vaccine's efficacy against severe COVID\u201019 did not diminish over time for patients who received two doses of the inactivated vaccine.\u00a0The disease types and clinical manifestations were generally mild in patients infected with the Delta variant, possibly associated with widespread vaccination with inactivated vaccines in China.\n                  <\/jats:p>","DOI":"10.1002\/jmv.27759","type":"journal-article","created":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T03:43:35Z","timestamp":1648871015000},"page":"3613-3624","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Inactivated vaccines prevent severe COVID\u201019 in patients infected with the Delta variant: A comparative study of the Delta and Alpha variants from China"],"prefix":"10.1002","volume":"94","author":[{"given":"Chanyuan","family":"Ye","sequence":"first","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Lv","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Kuang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisha","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine Zhejiang University Hangzhou 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College of Medicine Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Affiliated Hospital of Shaoxing University  Shaoxing Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huajiang","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Affiliated Hospital of Shaoxing University  Shaoxing Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9673-0969","authenticated-orcid":false,"given":"Yida","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for 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