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Here, we used quantitative liquid chromatography\u2010tandem mass spectrometry (LC\u2013MS\/MS) to identify differentially expressed proteins (DEPs) in plasma collected from patients with AIDS\u2010NHL and human immunodeficiency virus (HIV)\u2010infected patients without NHL (HIV\n                    <jats:sup>+<\/jats:sup>\n                    ). Proteins with a log2 (fold change) in abundance &gt;0.26 and\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05\u00a0were considered differentially abundant. In total, 84 DEPs were identified, among which 20 were further validated as potential biomarkers, with immunoglobulin and complement components being the most common proteins. Some of the proteins were further verified in a retrospective analysis of the medical records of patients in a larger cohort. These markedly altered proteins were found to mediate pathophysiological pathways that likely contribute to AIDS\u2010NHL pathogenesis, such as the humoral immune response, complement activation, and complement and coagulation cascades. Our findings provide a new molecular understanding of AIDS\u2010NHL pathogenesis and provide new evidence supporting the identification of these proteins as possible biomarkers in AIDS\u2010NHL.\n                  <\/jats:p>","DOI":"10.1002\/jmv.27775","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:29:57Z","timestamp":1649809797000},"page":"3876-3889","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Plasma proteomic analysis reveals altered protein abundances in HIV\u2010infected patients with or without non\u2010Hodgkin lymphoma"],"prefix":"10.1002","volume":"94","author":[{"given":"Ke","family":"Zhuang","sequence":"first","affiliation":[{"name":"ABSL\u2010III Laboratory at the Center for Animal Experiment, State Key Laboratory of Virology Wuhan University Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Zhongnan Hospital of Wuhan University Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingzheng","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Zhongnan Hospital of Wuhan University Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Zhongnan Hospital of Wuhan University Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences Wuhan University Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences Wuhan University Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanghua","family":"Mei","sequence":"additional","affiliation":[{"name":"Hubei Provincial Center for Disease Control and Prevention Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoxin","family":"Huang","sequence":"additional","affiliation":[{"name":"SpecAlly Life Technology Co., Ltd. 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