{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T21:32:47Z","timestamp":1784842367198,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Vaccination certainly is the best way to fight against the COVID\u201019 pandemic. In this study, the seroconversion effectiveness of two vaccines against severe acute respiratory syndrome coronavirus 2 was assessed in healthcare workers: virus\u2010inactivated CoronaVac (CV,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009303), and adenovirus\u2010vectored Oxford\u2013AstraZeneca (AZ,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009447). The immunoglobulin G (IgG) antibodies anti\u2010spike glycoprotein and anti\u2010nucleocapsid protein were assessed by enzyme\u2010linked immunosorbent assay\u00a0at the time before vaccination (T1), before the second dose (T2), and 30 days after the second dose (T3). Of all individuals vaccinated with AZ, 100% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009447) exhibited seroconversion, compared to 91% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009276) that were given CV vaccine. Among individuals who did not respond to the CV, only three individuals showed a significant increase in the antibody level 4 months later the booster dose. A lower seroconversion rate was observed in elders immunized with the\u00a0CV vaccine probably due to the natural immune senescence, or peculiarity of this vaccine. The AZ vaccine induced a higher humoral response; however, more common side effects were also observed. Nonvaccinated convalescent individuals revealed a similar rate of anti\u2010spike IgG to individuals that were given two doses of CV vaccine, which suggests that only a one\u2010shot COVID\u201019 vaccine could produce an effective immune response in convalescents.\n                  <\/jats:p>","DOI":"10.1002\/jmv.27782","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T08:56:40Z","timestamp":1649926600000},"page":"3714-3721","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Sequential IgG antibody monitoring for virus\u2010inactivated and adenovirus\u2010vectored COVID\u201019 vaccine in Brazilian healthcare workers"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7027-7748","authenticated-orcid":false,"given":"Hui T.","family":"Lin\u2010Wang","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Investigation in Cardiology, Research Division Dante Pazzanese Institute of Cardiology S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6669-1869","authenticated-orcid":false,"given":"Rogerio C.","family":"Lemes","sequence":"additional","affiliation":[{"name":"Statistic and Epidemiology Laboratory, Research Division Dante Pazzanese Institute of Cardiology S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8994-8345","authenticated-orcid":false,"given":"Eduardo","family":"da Silva Farias","sequence":"additional","affiliation":[{"name":"Statistic and Epidemiology Laboratory, Research Division Dante Pazzanese Institute of Cardiology S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3371-1143","authenticated-orcid":false,"given":"Marcio C.","family":"Bajgelman","sequence":"additional","affiliation":[{"name":"Brazilian National Laboratory for biosciences (LNBio) Brazilian National Center for Research in Energy and Materials (CNPEM) Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0190-6635","authenticated-orcid":false,"given":"Kleber G.","family":"Franchini","sequence":"additional","affiliation":[{"name":"Brazilian National Laboratory for biosciences (LNBio) Brazilian National Center for Research in Energy and Materials (CNPEM) Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2134-473X","authenticated-orcid":false,"given":"Renata","family":"Viana","sequence":"additional","affiliation":[{"name":"Research Division Dante Pazzanese Institute of Cardiology S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9176-2163","authenticated-orcid":false,"given":"Carlos","family":"Gun","sequence":"additional","affiliation":[{"name":"Research Division Dante Pazzanese Institute of Cardiology S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-020-03874-z"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.48991"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.06.052"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.58728"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30566-3"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2020.108427"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1839"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-020-03263-6"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25770"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.20.23034"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/v12050526"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2020.12.011"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.585354"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30843-4"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27098"},{"key":"e_1_2_10_18_1","unstructured":"Efic\u00e1cia global da Coronavac \u00e9 de 50 38% anuncia governo paulista. 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