{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T14:04:12Z","timestamp":1771250652718,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T00:00:00Z","timestamp":1651622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T00:00:00Z","timestamp":1651622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Peripheral blood smear (PBS) changes in coronavirus disease 2019 (COVID\u201019) are diverse and have been reported in the literature in the form of case series with relatively smaller sample sizes and with a handful of studies showing the association between PBS and clinical severity. This study aims to highlight the numerical and morphological changes in peripheral blood of COVID\u201019 patients and to compare the same in intensive care unit (ICU) and non\u2010ICU settings as well as with disease severity and outcome. The study included 80 COVID\u201019 positive (41 ICU and 39 non\u2010ICU) patients and 32 COVID\u201019 negative ICU patients. Complete blood counts (CBCs) and PBS findings were studied and scored by two pathologists blindfolded. Absolute lymphocyte count (ALC) and absolute eosinophil count (AEC) were significantly lower in COVID\u201019 positive cases as compared to the COVID\u201019 negative group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001 and\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001). COVID\u201019 positive group showed significant left myeloid shift (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.021), Dohle bodies (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.025) with significant prominence of acquired pseudo\u2013Pelger\u2013Hu\u00ebt anomaly, ring\u2010shaped neutrophils, monolobate neutrophils, and plasmacytoid lymphocytes as compared to control group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.000,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.009,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.046, and\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.011, respectively). The overall mean white blood cell (WBC) counts were higher in COVID\u201019 positive ICU patients as compared to non\u2010ICU COVID patients with significant shift to left, presence of ring\u2010shaped neutrophils, monocyte vacuolation, and large granular lymphocytes (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.017,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.007,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.008, and\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004, respectively). Deceased group showed significantly higher WBC count (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.018) with marked neutrophilia (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.024) and toxic granulation (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01) with prominence of monocyte vacuolization, ring\u2010shaped neutrophils, large granular lymphocytes, and reactive lymphocytes. Parameters like myeloid left shift, ring\u2010shaped neutrophils, monocyte vacuolation, and large granular lymphocytes emerged as highly sensitive markers of disease severity. Therefore, serial CBC with comprehensive PBS analysis should be done in every newly diagnosed hospitalized COVID\u201019 patient which potentially predicts the course of the disease.\n                  <\/jats:p>","DOI":"10.1002\/jmv.27793","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T05:23:34Z","timestamp":1650864214000},"page":"3757-3767","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Comparison of hematologic abnormalities between hospitalized coronavirus disease 2019\u00a0positive and negative patients with correlation to disease severity and outcome"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0482-2082","authenticated-orcid":false,"given":"Swasti","family":"Jain","sequence":"first","affiliation":[{"name":"Department of Pathology Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachana","family":"Meena","sequence":"additional","affiliation":[{"name":"Department of Pathology Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pathology Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranvinder","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umesh","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Pathology Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2002032"},{"key":"e_1_2_11_3_1","unstructured":"World Health Organization. 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