{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:35:16Z","timestamp":1784421316128,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The human immunodeficiency virus (HIV) belongs to the Retroviridae family and remains a public health problem in sub\u2010Saharan Africa. Recent reports from WHO have shown that 33 million people died from HIV infections. HIV is one of the most serious fatal human diseases of the 20th\u00a0and 21st\u00a0centuries. However, variations in genetic and immunological factors are associated with protection against HIV infection in uninfected people exposed to HIV. This is the case with naturals killers which play an important role in the progression or regression of HIV infection. The objective of this study is to characterize certain <jats:italic>HLA<\/jats:italic> (human leukocyte antigen) <jats:italic>class II<\/jats:italic> genes and <jats:italic>KIR<\/jats:italic> genes in HIV\u20101 serodiscordant couples in Burkina Faso. This study was carried out at Burkina Faso among nineteen (19) HIV\u20101 serodiscordant couples. Classical multiplex PCR (SSP\u2010PCR) was used to characterize the presence or absence of the <jats:italic>KIR<\/jats:italic> genes and certain <jats:italic>class II HLAs<\/jats:italic> (<jats:italic>DRB1*11<\/jats:italic> and <jats:italic>DRB1*12<\/jats:italic>). The characterization of the <jats:italic>KIR<\/jats:italic> and <jats:italic>HLA<\/jats:italic> genes <jats:italic>DRB1*11<\/jats:italic>, <jats:italic>DRB1*12<\/jats:italic> in this study demonstrated that the inhibitor <jats:italic>KIR2DL5B<\/jats:italic>, would confer protection against HIV\u20101 infection in seronegative partners (odd ratio [OR]\u2009=\u20090.13 [0.02\u22120.72]\u00a0and <jats:italic>p<\/jats:italic>\u2009=\u20090.029), and the <jats:italic>HLA DRB1*12<\/jats:italic> allele was associated with protection against HIV\u20101 infection in seronegative partners (OR\u2009=\u20090.16 [0.03\u22120.77]\u00a0and <jats:italic>p<\/jats:italic>\u2009=\u20090.038). AA and Bx haplotypes were not found to be associated with HIV\u20101 infection in serodiscordant couples. This study confirms the involvement of the <jats:italic>KIR<\/jats:italic> genes in viral pathologies such as HIV\u20101 infection. Future larger\u2010scale studies may provide a better understanding of the molecular mechanism by which the KIR haplotype and combination of <jats:italic>KIR\/HLA<\/jats:italic> are associated with protection against HIV infection.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.27821","type":"journal-article","created":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T02:10:23Z","timestamp":1651543823000},"page":"4425-4432","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["KIR2DL5B and HLA DRB1*12 alleles seems to be associated with protection against HIV\u20101 in serodiscordant couples in Burkina Faso"],"prefix":"10.1002","volume":"94","author":[{"given":"Tatiana Doriane","family":"Lallogo","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Microbiology, Molecular Biology and Genetics Laboratory (LABIOGENE) University Joseph Ki\u2010Zerbo  Ouagadougou Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6895-6725","authenticated-orcid":false,"given":"Florencia W.","family":"Djigma","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Microbiology, Molecular Biology and Genetics Laboratory (LABIOGENE) University Joseph Ki\u2010Zerbo  Ouagadougou Burkina Faso"},{"name":"Pietro Annigoni Biomolecular Research Center (CERBA)  Ouagadougou Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pegdwend\u00e9 Abel","family":"Sorgho","sequence":"additional","affiliation":[{"name":"Pietro Annigoni Biomolecular Research Center (CERBA)  Ouagadougou Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy James","family":"Martinson","sequence":"additional","affiliation":[{"name":"Laboratory of Infectious Diseases\/Microbiology University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00e9gwind\u00e9 Rebeca","family":"Compaore","sequence":"additional","affiliation":[{"name":"Institute for Research in Health Sciences, IRSS Ouagadougou Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lassina","family":"Traore","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Microbiology, Molecular Biology and Genetics Laboratory (LABIOGENE) University Joseph Ki\u2010Zerbo  Ouagadougou Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prosper","family":"Bado","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Microbiology, Molecular Biology and Genetics Laboratory (LABIOGENE) University Joseph Ki\u2010Zerbo  Ouagadougou Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bapio Val\u00e9rie Elvira Jean T\u00e9lesphore","family":"Bazie","sequence":"additional","affiliation":[{"name":"Pietro Annigoni Biomolecular Research Center (CERBA)  Ouagadougou Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanyo Jospin","family":"Amegnona","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Microbiology, Molecular Biology and Genetics Laboratory (LABIOGENE) University Joseph Ki\u2010Zerbo  Ouagadougou Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Th\u00e9r\u00e8se S.","family":"Kagone","sequence":"additional","affiliation":[{"name":"National Institute of Public Health Bobo\u2010Dioulasso Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogomenoma Alice","family":"Ouedraogo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Microbiology, Molecular Biology and Genetics Laboratory (LABIOGENE) University Joseph Ki\u2010Zerbo  Ouagadougou Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise P.","family":"Ilboudo","sequence":"additional","affiliation":[{"name":"University of Fada N'Gourma N'Gourma Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorcas","family":"Obiri\u2010Yeboah","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, School of Medical Sciences University of Cape Coast  Cape Coast Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert T.","family":"Yonli","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Microbiology, Molecular Biology and Genetics Laboratory (LABIOGENE) University Joseph Ki\u2010Zerbo  Ouagadougou Burkina Faso"},{"name":"Pietro Annigoni Biomolecular Research Center (CERBA)  Ouagadougou Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Simpore","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Microbiology, Molecular Biology and Genetics Laboratory (LABIOGENE) University Joseph Ki\u2010Zerbo  Ouagadougou Burkina Faso"},{"name":"Pietro Annigoni Biomolecular Research Center (CERBA)  Ouagadougou Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,12]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"UNAIDS. Focus on Burkina Faso [WWW Document]. 2017. Accessed March 19 2021.\u00a0https:\/\/www.unaids.org\/fr\/20190402_country_focus_BurkinaFaso"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283196a80"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1995-7645(14)60211-X"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1515\/bmc-2019-0024"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-016-0906-1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3282f56b23"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng934"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.10.6588"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-08-040238"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-09-077438"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2010.03398.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2010.04095.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1140"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-002-0463-7"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-009-0378-7"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2007.01.019"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.54.101601.152346"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/315472"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(97)00092-X"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.162.11.6942"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0303.970323"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11275"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-362-6_25"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/891402"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2008.1200"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10051088"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146386"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.4081\/jphia.2018.907"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.4084\/mjhid.2018.060"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1515\/biol-2021-0113"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364367"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24348"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-405"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiq075"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2008.57"},{"key":"e_1_2_9_37_1","first-page":"143","article-title":"HLA class II (DRB1, DQA1 and DQB1) allele and haplotype frequencies among HIV\u2010infection discordant Thai couples","volume":"22","author":"Bejrachandra S","year":"2004","journal-title":"Asian Pac J Allergy Immunol"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.27821","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.27821","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.27821","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T07:24:31Z","timestamp":1692775471000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.27821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,12]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1002\/jmv.27821"],"URL":"https:\/\/doi.org\/10.1002\/jmv.27821","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,12]]},"assertion":[{"value":"2022-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}