{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T06:21:08Z","timestamp":1769581268660,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Interleukin 10 (IL\u201010) is an immunosuppressive cytokine and its genetic variants could have an indirect impact on viral biology and human papillomavirus\u00a0(HPV) E6\/E7 messenger RNA\u00a0(mRNA) expression as well. This study evaluates the association between IL\u201010\u2010592 C\/A (rs1800872) single\u2010nucleotide polymorphism\u00a0and HPV E6\/E7 mRNA expression in a group of women from the Republic of North Macedonia. Using a commercial test, 272 women's cervical samples were analyzed for HPV E6\/E7 mRNA and HPV DNA presence. The cases were stratified into three groups: double\u2010positive (<jats:italic>n<\/jats:italic>\u2009=\u2009108, positive for both tests), negative (<jats:italic>n<\/jats:italic>\u2009=\u200951, negative for HPV E6\/E7 mRNA and HPV DNA positive), and the control group (<jats:italic>n<\/jats:italic>\u2009=\u2009113, negative for both tests). The IL\u201010\u2010592 C\/A polymorphism was analyzed using polymerase chain reaction\u2010restriction fragment length polymorphism. The results showed the CC genotype and the C allele frequencies of IL\u201010\u2010592C\/A were significantly higher in double\u2010positive (59.3% and 78.2%) compared to negative group (39.2% and 65.7%), (<jats:italic>p<\/jats:italic>\u2009=\u20090.018, confidence interval [CI]\u2009=\u20092.25; 1.14\u20134.45 and <jats:italic>p<\/jats:italic>\u2009=\u20090.016, CI\u2009=\u20091.88; 1.11\u20133.16, respectively). The CC genotype and C allele of rs1800872 polymorphism were shown to be associated with HPV E6\/E7 mRNA but not with HPV DNA positivity, which implies a possible role of this polymorphism in the course of the infection only after HPV onset, and lack of association with the susceptibility to HPV.<\/jats:p>","DOI":"10.1002\/jmv.27858","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T07:33:38Z","timestamp":1652772818000},"page":"4485-4489","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["HPV E6\/E7mRNA association with interleukin 10 (rs1800872) polymorphism in a group of Macedonian women"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8587-7386","authenticated-orcid":false,"given":"Sotirija","family":"Duvlis","sequence":"first","affiliation":[{"name":"Faculty of Medical Sciences \u201cGoce Delcev\u201d University \u0160tip Republic of North Macedonia"},{"name":"Laboratory for Virology Institute of Public Health of Republic of North Macedonia Skopje Republic of North Macedonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Drage","family":"Dabeski","sequence":"additional","affiliation":[{"name":"University Clinic for Gynecology and Obstetrics, Medical Faculty Ss. Cyril and Methodius University in Skopje, Skopje, Republic of north Macedonia Skopje Republic of North Macedonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marija","family":"Hiljadnikova\u2010Bajro","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy,\u00a0Institute for Applied Biochemistry Ss. Cyril and Methodius University in Skopje Skopje Republic of North Macedonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dugagjin","family":"Osmani","sequence":"additional","affiliation":[{"name":"Laboratory for Virology Institute of Public Health of Republic of North Macedonia Skopje Republic of North Macedonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaban","family":"Memeti","sequence":"additional","affiliation":[{"name":"Laboratory for Virology Institute of Public Health of Republic of North Macedonia Skopje Republic of North Macedonia"},{"name":"University Clinic for Plastic Surgery, Medical Faculty Ss. Cyril and Methodius University in Skopje Skopje Republic of North Macedonia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-419X(96)00020-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2007.11.002"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.03116"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012724"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-011981"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0306"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737159.8.4.405"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01315-10"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200301000-00005"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1105436"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-004-3607-7"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2017.03.002"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-020-00790-x"},{"issue":"1","key":"e_1_2_9_15_1","first-page":"132","article-title":"Association of IL\u201010 (rs1800872) and IL\u20104R (rs1805010) polymorphisms with cervical intraepithelial lesions and cervical carcinomas","volume":"25","author":"Duvlis S","year":"2020","journal-title":"J\u00a0BUON"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057246"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2005.17"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2017.08.005"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2017.05.020"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1492"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.05.089"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1210379"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(02)00070-0"},{"issue":"8","key":"e_1_2_9_24_1","first-page":"45994","article-title":"The impact of interleukin\u201010 (IL\u201010) gene 4 polymorphisms on peripheral blood IL\u201010 variation and prostate cancer risk based on published studies","volume":"11","author":"Men T","year":"2013","journal-title":"Oncotarget"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000023892"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.27858","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.27858","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.27858","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T07:26:43Z","timestamp":1692775603000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.27858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,31]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1002\/jmv.27858"],"URL":"https:\/\/doi.org\/10.1002\/jmv.27858","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,31]]},"assertion":[{"value":"2022-05-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}