{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T01:30:58Z","timestamp":1781227858334,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T00:00:00Z","timestamp":1653696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We aimed to analyze the efficacy and safety of an inactivated SARS\u2010CoV\u20102 vaccine in people living with HIV (PLWH). A total of 143 PLWH and 50 healthy individuals were included in this study. A commercially available magnetic chemiluminescence enzyme immunoassay kit was used to detect serum IgG and IgM antibodies against SARS\u2010CoV\u20102. Serum levels of SARS\u2010CoV\u20102\u2010specific IgG were significantly higher in the control group than in the PLWH group (<jats:italic>p<\/jats:italic>\u2009=\u20090.001). Overall, 76% of individuals in the control group were detected with seropositivity IgG against SARS\u2010CoV\u20102 compared to 58% in the PLWH group (<jats:italic>p<\/jats:italic>\u2009=\u20090.024). In PLWH with IgG seropositivity, CD4+ T\u2010cell counts before antiretroviral therapy (ART) was higher (<jats:italic>p<\/jats:italic>\u2009=\u20090.015). Multivariable analysis indicated that CD4+ T cells at IgG detection (odds ratio [OR]\u2009=\u20091.004, <jats:italic>p<\/jats:italic>\u2009=\u20090.006) and time after vaccination (OR\u2009=\u20090.977, <jats:italic>p<\/jats:italic>\u2009=\u20090.014) were independently associated with seropositivity IgG against SARS\u2010CoV\u20102 in PLWH. Neutralizing antibody (nAb) titers in PLWH against wild\u2010type SARS\u2010CoV\u20102 were similar to those in the control group (<jats:italic>p<\/jats:italic>\u2009=\u20090.160). The proportion of seropositive nAbs against wild\u2010type SARS\u2010CoV\u20102 was also similar (95% in the control group vs. 97% in the\u00a0PLWH group, <jats:italic>p<\/jats:italic>\u2009=\u20090.665). Similar results were obtained when nAb was detected against the delta variants with similar titers (<jats:italic>p<\/jats:italic>\u2009=\u20090.355) and a similar proportion of seropositive nAbs were observed (<jats:italic>p<\/jats:italic>\u2009=\u20090.588). All the side effects observed in our study were mild and self\u2010limiting. The inactivated COVID\u201019 vaccine appears to be safe with good immunogenicity in Chinese PLWH.<\/jats:p>","DOI":"10.1002\/jmv.27872","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T02:10:43Z","timestamp":1652926243000},"page":"4224-4233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Immunogenicity and safety of an inactivated SARS\u2010CoV\u20102 vaccine in people living with HIV: A cross\u2010sectional study"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3765-9127","authenticated-orcid":false,"given":"Shaohang","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Nanfang Hospital Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guichan","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Nanfang Hospital Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Nanfang Hospital Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiqing","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Nanfang Hospital Southern Medical University Guangzhou China"},{"name":"Department of Infectious Diseases Shunde Hospital Affiliated to Southern Medical University Shunde China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirong","family":"Zou","sequence":"additional","affiliation":[{"name":"Center for Disease Control and Prevention of Guangdong Province Institute of Microbiology Guangzhou 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