{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T11:42:23Z","timestamp":1770464543316,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T00:00:00Z","timestamp":1654732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cabotegravir and rilpivirine are the first drugs to be approved as injectable therapy to treat individuals with HIV. Despite encouraging results, the guidelines specify strict criteria for eligibility that could limit the feasibility of this strategy. We collected the clinical data of HIV\u2010positive patients who were being treated at a single, third\u2010level center in Italy. All patients were on stable therapy and showed suppressed viral load on their most recent analyses. We performed a cross\u2010sectional analysis of the clinical and viro\u2010immunological characteristics of this population and excluded patients who\u00a0had previous virological failures, resistance\u2010associated mutations\u00a0(RAMs) to rilpivirine or integrase inhibitors in the historical genotype, hepatitis B infection, absence of previous genotypes, and the coexistence of HIV\u2010subtype A and obesity. Our aim was to evaluate the proportion of patients who could be eligible for switching to this strategy. one thousand seven hundred fifty\u2010two\u00a0patients were eligible. One hundred and forty\u2010eight\u00a0were excluded because of a detectable viral load. With regard to the exclusion criteria, 48 patients had coinfection with hepatitis B virus, and 744 had a history of previous virological failures. Of the 896 patients with at least one genotypic resistance test, 161 had one or more RAMs to rilpivirine and 3 had RAMs to cabotegravir. None of the patients presented the combination of obesity and the A viral subtype. Overall, 31.2% of the patients were ineligible for cabotegravir\u2013rilpivirine, and the proportion increased to 47.3% when we considered only patients with all available information concerning resistance tests. Approximately half of our cohort of patients did not fulfill the criteria and even more patients were potentially ineligible for cabotegravir\u2013rilpivirine due to the lack of genotypic resistance tests. Also, fertile women had to be excluded due to the lack of data about this combination during pregnancy and breastfeeding.<\/jats:p>","DOI":"10.1002\/jmv.27890","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T07:14:31Z","timestamp":1653981271000},"page":"4970-4974","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Are we ready for long\u2010acting? A feasibility evaluation of long\u2010acting cabotegravir\u2013rilpivirine in clinical practice"],"prefix":"10.1002","volume":"94","author":[{"given":"Alberto","family":"Borghetti","sequence":"first","affiliation":[{"name":"Fondazione Policlinico Universitario A. 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