{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T09:07:36Z","timestamp":1770628056495,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T00:00:00Z","timestamp":1654905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Almost all chronic hepatitis C (CHC) patients can achieve sustained virological response (SVR) with direct\u2010acting antivirals. However, the development of hepatocellular carcinoma (HCC), even after the achievement of SVR, continues to be a serious problem. The aim of this study was to assess the association between host genetic factors and de novo HCC after SVR. This single\u2010center, retrospective study consisted of 442 consecutive CHC patients without a history of HCC who achieved SVR through interferon (IFN)\u2010based and IFN\u2010free therapy. Predictive factors associated with the development of HCC were determined by the Cox proportional hazards model. The single\u2010nucleotide polymorphism (SNP) genotyping data of 223 patients were available for analysis. Of the seven SNPs analyzed in this study, only the patatin\u2010like phospholipase domain containing 3 (PNPLA3) rs738409 GG genotype was significantly, positively associated with the development of de novo HCC after adjusting for age, sex, and fibrosis status (adjusted hazard ratio [aHR] 5.66, <jats:italic>p<\/jats:italic>\u2009=\u20090.003). In multivariable analysis, age (aHR 1.05, <jats:italic>p<\/jats:italic>\u2009=\u20090.007), advanced fibrosis (aHR 2.69, <jats:italic>p<\/jats:italic>\u2009=\u20090.019), \u03b1\u2010fetoprotein at post\u201012 weeks of treatment \u22657.0\u2009ng\/ml (aHR 3.85, <jats:italic>p<\/jats:italic>\u2009=\u20090.001), and PNPLA3 GG genotype (aHR 3.02, <jats:italic>p<\/jats:italic>\u2009=\u20090.004) were extracted as independent predictors of the development of de novo HCC. In conclusion, the PNPLA3 genotype was independently associated with the de novo HCC of CHC patients who achieved SVR. Such detailed knowledge of host genetic factors will be useful for HCC surveillance after HCV elimination.<\/jats:p>","DOI":"10.1002\/jmv.27904","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T07:54:25Z","timestamp":1654156465000},"page":"5007-5014","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of the PNPLA3 genotype on the risk of hepatocellular carcinoma after hepatitis C virus eradication"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8371-9904","authenticated-orcid":false,"given":"Azusa","family":"Ohta","sequence":"first","affiliation":[{"name":"Department of Environmental Medicine and Infectious Disease Kyushu University Graduate School of Medical Sciences  Fukuoka Japan"},{"name":"Department of General Internal Medicine Kyushu University Hospital  Fukuoka 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