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Human polyclonal antibodies (hpAbs) can be made from convalescent human donor serum, although it is considered limited due to pandemics and the urgent requirement. Additionally, polyclonal antibodies (pAbs) could be generated from animals, but they may cause severe immunoreactivity and, once \"humanized,\" may have lower neutralization efficiency. Transchromosomic bovines (TcBs) have been developed to address these concerns by creating robust neutralizing hpAbs, which are useful in preventing and\/or curing human infections in response to hyperimmunization with vaccines holding adjuvants and\/or immune stimulators over an extensive period. Unlike other animal\u2010derived pAbs, potent hpAbs could be promptly produced from TcB in large amounts to assist against an outbreak scenario. Some of these highly efficacious TcB\u2010derived antibodies have already neutralized and blocked diseases in clinical studies. Severe acute respiratory syndrome coronavirus 2\u00a0(SARS\u2010CoV\u20102) has numerous variants classified into variants of concern (VOCs), variants of interest (VOIs), and variants under monitoring. Although these variants possess different mutations, such as N501Y, E484K, K417N, K417T, L452R, T478K, and P681R, SAB\u2010185 has shown broad neutralizing activity against VOCs, such as Alpha, Beta, Gamma, Delta, and Omicron variants, and VOIs, such as Epsilon, Iota, Kappa, and Lambda variants. This article highlights recent developments in the field of bovine\u2010derived biotherapeutics, which are seen as a practical platform for developing safe and effective antivirals with broad activity, particularly considering emerging viral infections such as SARS\u2010CoV\u20102, Ebola, Middle East respiratory syndrome coronavirus, Zika, human immunodeficiency virus\u00a0type\u00a01, and influenza A virus. Antibodies in the bovine serum or colostrum, which have been proved to be more protective than their human counterparts, are also reviewed.<\/jats:p>","DOI":"10.1002\/jmv.27907","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T03:38:34Z","timestamp":1654227514000},"page":"4599-4610","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Transchromosomic bovines\u2010derived broadly neutralizing antibodies as potent biotherapeutics to counter important emerging viral pathogens with a special focus on SARS\u2010CoV\u20102, MERS\u2010CoV, Ebola, Zika, HIV\u20101, and influenza A virus"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8616-5874","authenticated-orcid":false,"given":"AbdulRahman A.","family":"Saied","sequence":"first","affiliation":[{"name":"National Food Safety Authority (NFSA) Aswan Egypt"},{"name":"Ministry of Tourism and Antiquities Aswan Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela Sales Lima","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, Biosciences Center Federal University of Rio Grande do Norte Natal Rio Grande do Norte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano Henrique","family":"do Nascimento Rangel","sequence":"additional","affiliation":[{"name":"Specialized Academic Unit in Agricultural Sciences Federal University of Rio Grande do Norte Natal Maca\u00edba\u2010Rio Grande do Norte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Skowron","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Nicolaus Copernicus University in Toru\u0144 L. 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