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The aim of this study was to determine the antibody response after two doses of homologous or heterologous severe acute respiratory syndrome coronavirus 2\u00a0(SARS\u2010CoV\u20102) vaccines and to identify the factors affecting this response among healthcare workers\u00a0(HCWs) at health promotion centers.\u00a0In this prospective observational study, 1095 consenting HCWs were recruited from 16 health checkup centers and were tested at T0 (day of first dose), T1\u20101 (1 month after first dose), T2\u20100 (day of second dose), T2\u20101 (1 month after second dose), and T2\u20103 (3 months after second dose). SARS\u2010CoV\u20102 antibodies were measured using a chemiluminescence microparticle immunoassay with SARS\u2010CoV\u20102 IgG II Quant in the ARCHITECT system (Abbott Diagnostics).\u00a0At T1\u20101, anti\u2010SARS\u2010CoV\u20102 S\u2010RBD IgG levels were significantly higher in participants who received messenger\u00a0RNA (mRNA) vaccines than in those who received viral vector vaccines (<jats:italic>p\u2009<\/jats:italic>&lt;\u20090.001). At T2\u20101, anti\u2010SARS\u2010CoV\u20102 S\u2010RBD IgG levels were about 10 times higher than at T1\u20101 in participants who received homologous mRNA vaccines, which decreased to a third of those at T2\u20103. Anti\u2010SARS\u2010CoV\u20102 S\u2010RBD IgG levels were highest among those who received homologous mRNA vaccines, followed by heterologous mRNA viral vector vaccines and homologous viral vector vaccines at T2\u20103 (<jats:italic>p\u2009<\/jats:italic>&lt;\u20090.001). In a multivariable linear regression analysis, being female, taking at least one mRNA vaccine, and having a history of recovery from coronavirus disease 2019\u00a0(COVID\u201019) were significantly associated with anti\u2010S\u2010RBD levels.\u00a0Anti\u2010SARS\u2010CoV\u20102 S\u2010RBD IgG levels were decreased at 3 months after two\u2010dose vaccinations and were associated with sex, vaccine type, and COVID\u201019 history.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.27911","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T05:51:17Z","timestamp":1654235477000},"page":"4719-4726","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Antibody response after two doses of homologous or heterologous SARS\u2010CoV\u20102 vaccines in healthcare workers at health promotion centers: A prospective observational study"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0637-4364","authenticated-orcid":false,"given":"Eun\u2010Hee","family":"Nah","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Health Promotion Research Institute Korea Association of Health Promotion  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seon","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Health Promotion Research Institute Korea Association of Health Promotion  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeran","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Health Promotion Research Institute Korea Association of Health Promotion  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Health Promotion Research Institute Korea Association of Health Promotion  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongwon","family":"Noh","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Health Promotion Research Institute Korea Association of Health Promotion  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunjoo","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Health Promotion Research Institute Korea Association of Health Promotion  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han\u2010Ik","family":"Cho","sequence":"additional","affiliation":[{"name":"MEDIcheck LAB, Korea Association of Health Promotion  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,14]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization (WHO). 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