{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T08:04:52Z","timestamp":1771661092096,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T00:00:00Z","timestamp":1655337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Comorbidities such as hypertension could exacerbate symptoms of coronaviral disease 2019 (COVID)\u201019 infection. Patients with hypertension may receive both anti\u2010COVID\u201019 and antihypertension therapies when infected with COVID\u201019. However, it is not clear how different classes of anti\u2010hypertension drugs impact the outcome of COVID\u201019 treatment. Herein, we explore the association between the inpatient use of different classes of anti\u2010hypertension drugs and mortality among patients with hypertension hospitalized with COVID\u201019. We totally collected data from 278 patients with hypertension diagnosed with COVID\u201019 admitted to hospitals in Wuhan from February 1 to April 1, 2020. A retrospective study was conducted and single\u2010cell RNA\u2010sequencing (RNA\u2010Seq) analysis of treatment\u2010related genes was performed. The results showed that Angiotensin II receptor blocker (ARB) and calcium channel blocker (CCB) drugs significantly increased the survival rate but the use of angiotensin\u2010converting enzyme inhibitor\/\u03b2\u2010block\/diuretic drugs did not affect the mortality caused by COVID\u201019. Based on the analysis of four public data sets of single\u2010cell RNA\u2010Seq on COVID\u201019 patients, we concluded that <jats:italic>JUN<\/jats:italic>, <jats:italic>LST1<\/jats:italic> genes may play a role in the effect of ARB on COVID\u201019\u2010related mortality, whereas <jats:italic>CALM1<\/jats:italic> gene may contribute to the effect of CCB on COVID\u201019\u2010related mortality. Our results provide guidance on the selection of antihypertension drugs for hypertensive patients infected with COVID\u201019.<\/jats:p>","DOI":"10.1002\/jmv.27914","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T07:19:15Z","timestamp":1654240755000},"page":"4727-4734","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The clinical and bioinformatics analysis for the role of antihypertension drugs on mortality among patients with hypertension hospitalized with COVID\u201019"],"prefix":"10.1002","volume":"94","author":[{"given":"Liyang","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health Sciences University of Macau  Taipa, Macau China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health Sciences University of Macau  Taipa, Macau China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjuan","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Zhongnan Hospital of Wuhan University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo","family":"Yan","sequence":"additional","affiliation":[{"name":"Institute of Cell and Neurobiology Charit\u00e9 Medical University  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medicine Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sridhar","family":"Radhakrishnan","sequence":"additional","affiliation":[{"name":"Cancer Science Institute of Singapore National University of Singapore  Singapore 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