{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:52:57Z","timestamp":1771660377195,"version":"3.50.1"},"reference-count":55,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T00:00:00Z","timestamp":1655164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Olfactory disorders (OD) pathogenesis, underlying conditions, and prognostic in coronavirus disease 2019 (COVID\u201019) remain partially described. ANOSVID is a retrospective study in <jats:italic>Nord Franche\u2010Comt\u00e9<\/jats:italic> Hospital (France) that included COVID\u201019 patients from March 1 2020 to May 31 2020. The aim was to compare COVID\u201019 patients with OD (OD group) and patients without OD (no\u2010OD group). A second analysis compared patients with anosmia (high OD group) and patients with hyposmia or no OD (low or no\u2010OD group). The OD group presented less cardiovascular and other respiratory diseases compared to the no\u2010OD group (odds ratio [OR]\u2009=\u20090.536 [0.293\u20130.981], <jats:italic>p<\/jats:italic>\u2009=\u20090.041 and OR\u2009=\u20090.222 [0.056\u20130.874], <jats:italic>p<\/jats:italic>\u2009=\u20090.037 respectively). Moreover, history of malignancy was less present in the high OD group compared with the low or no\u2010OD group (OR\u2009=\u20090.170 [0.064\u20130.455], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The main associated symptoms (OR\u2009&gt;\u20095) with OD were loss of taste (OR\u2009=\u200924.059 [13.474\u201342.959], <jats:italic>p<\/jats:italic>\u2009=\u20090.000) and cacosmia (OR\u2009=\u20095.821 [2.246\u201315.085], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Most of all ORs decreased in the second analysis, especially for general, digestive, and ENT symptoms. Only two ORs increased: headache (OR\u2009=\u20092.697 [1.746\u20134.167], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and facial pain (OR\u2009=\u20092.901 [1.441\u20135.842], <jats:italic>p<\/jats:italic>\u2009=\u20090.002). The high OD group had a higher creatinine clearance CKD than the low or no\u2010OD group (89.0\u2009\u00b1\u200921.1 vs. 81.0\u2009\u00b1\u200920.5, <jats:italic>p<\/jats:italic>\u2009=\u20090.040). No significant difference was found concerning the virological, radiological, and severity criteria. OD patients seem to have less comorbidity, especially better cardiovascular and renal function. Associated symptoms with OD were mostly neurological symptoms. We did not find a significant relationship between OD and less severity in COVID\u201019 possibly due to methodological bias.<\/jats:p>","DOI":"10.1002\/jmv.27918","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T01:59:15Z","timestamp":1654653555000},"page":"4762-4775","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Olfactory dysfunction in COVID\u201019, new insights from a cohort of 353 patients: The ANOSVID study"],"prefix":"10.1002","volume":"94","author":[{"given":"Julien","family":"Mercier","sequence":"first","affiliation":[{"name":"Department of Infectious Disease Nord Franche\u2010Comt\u00e9 Hospital  Tr\u00e9venans France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9598-2486","authenticated-orcid":false,"given":"Molka","family":"Osman","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of Tunis University Tunis El Manar  Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2177-4318","authenticated-orcid":false,"given":"Kevin","family":"Bouiller","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease University Hospital of Besan\u00e7on  Besan\u00e7on France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can","family":"Tipirdamaz","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Nord Franche\u2010Comt\u00e9 Hospital  Tr\u00e9venans France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Gendrin","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Nord Franche\u2010Comt\u00e9 Hospital  Tr\u00e9venans France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Chirouze","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease University Hospital of Besan\u00e7on  Besan\u00e7on France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2892-4216","authenticated-orcid":false,"given":"Quentin","family":"Lepiller","sequence":"additional","affiliation":[{"name":"Department of Virology University Hospital of Besan\u00e7on  Besan\u00e7on France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elodie","family":"Bouvier","sequence":"additional","affiliation":[{"name":"Clinical Research Unit, Nord Franche\u2010Comt\u00e9 Hospital  Tr\u00e9venans France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre\u2010Yves","family":"Royer","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Nord Franche\u2010Comt\u00e9 Hospital  Tr\u00e9venans France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alix","family":"Pierron","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Nord Franche\u2010Comt\u00e9 Hospital  Tr\u00e9venans France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynda","family":"Toko","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Nord Franche\u2010Comt\u00e9 Hospital  Tr\u00e9venans France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Plantin","sequence":"additional","affiliation":[{"name":"Department of Microbiology Nord Franche\u2010Comt\u00e9 Hospital  Tr\u00e9venans France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N'dri\u2010Juliette","family":"Kadiane\u2010Oussou","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Nord Franche\u2010Comt\u00e9 Hospital  Tr\u00e9venans France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3177-9806","authenticated-orcid":false,"given":"Souheil","family":"Zayet","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Nord Franche\u2010Comt\u00e9 Hospital  Tr\u00e9venans France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timoth\u00e9e","family":"Klopfenstein","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Nord Franche\u2010Comt\u00e9 Hospital  Tr\u00e9venans France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2012-7"},{"key":"e_1_2_9_3_1","unstructured":"WHO Coronavirus (COVID\u201019) Dashboard. Accessed August 24 2021.https:\/\/covid19.who.int"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2020.04.006"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2020.05.030"},{"key":"e_1_2_9_6_1","first-page":"1","article-title":"Contribution of anosmia and dysgeusia for diagnostic of COVID\u201019 in outpatients","volume":"14","author":"Zayet S","year":"2020","journal-title":"Infection"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858420956905"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-020-04056-7"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489420963165"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2020.117163"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-06455-0"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2196\/21866"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1945892420930954"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.18176\/jiaci.0595"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.08.012"},{"key":"e_1_2_9_16_1","first-page":"\u200b","article-title":"Olfactory dysfunction in COVID\u201019: a marker of good prognosis?","volume":"1","author":"Mendon\u00e7a CV","year":"2021","journal-title":"Braz J Otorhinolaryngol"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009937"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-06284-1"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2020.07.023"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13244-020-00939-7"},{"key":"e_1_2_9_21_1","first-page":"1","article-title":"COVID\u201019 anosmia and gustatory symptoms as a prognosis factor: a subanalysis of the HOPE COVID\u201019 (health outcome predictive evaluation for COVID\u201019) registry","volume":"1","author":"Porta\u2010Etessam J","year":"2021","journal-title":"Infection"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0237960"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2021.100268"},{"issue":"3","key":"e_1_2_9_24_1","first-page":"2001948","article-title":"Elevated ACE2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory SARS\u2010CoV\u20102 entry and replication","volume":"56","author":"Chen M","year":"2020","journal-title":"bioRxiv"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599820934380"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22593"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9081719"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-00758-5"},{"key":"e_1_2_9_29_1","first-page":"M20","article-title":"Loss of smell and taste in 2013 european patients with mild to moderate COVID\u201019","volume":"26","author":"Lechien JR","year":"2020","journal-title":"Ann Intern Med"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22392"},{"key":"e_1_2_9_31_1","first-page":"1","article-title":"Objective gustatory and olfactory dysfunction in COVID\u201019 patients: a prospective cross\u2010sectional study","volume":"20","author":"Singer\u2010Cornelius T","year":"2021","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"e_1_2_9_32_1","first-page":"1","article-title":"La f\u00e9minisation des professions de sant\u00e9 en France: donn\u00e9es de cadrage","author":"Bessi\u00e8re S","year":"2005","journal-title":"Rev Fr Aff Soc"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2020.1836397"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.09.039"},{"key":"e_1_2_9_35_1","first-page":"\u200b","article-title":"Correlation of olfactory dysfunction with lung involvement and severity of COVID\u201019","volume":"10","author":"Ya\u011fmur AR","year":"2021","journal-title":"Ir J Med Sci"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.0009"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2020.08.004"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhl135"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-020-10135-8"},{"key":"e_1_2_9_40_1","first-page":"e932962","article-title":"A review of neurological involvement in patients with SARS\u2010CoV\u20102 infection","volume":"27","author":"Xu Y","year":"2021","journal-title":"Med Sci Monit Int Med J Exp Clin Res"},{"key":"e_1_2_9_41_1","first-page":"\u200b","article-title":"Pathophysiological relationship between COVID\u201019 and olfactory dysfunction: a systematic review","volume":"25","author":"Las Casas Lima MH","year":"2021","journal-title":"Braz J Otorhinolaryngol"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101839"},{"key":"e_1_2_9_43_1","first-page":"28957","article-title":"Evolution of olfactory disorders in COVID\u201019 patients","volume":"2","author":"Gorzkowski V","year":"2020","journal-title":"Laryngoscope"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.06.032"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.10047"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00737-08"},{"key":"e_1_2_9_47_1","first-page":"1","article-title":"Multiple neuroinvasive pathways in COVID\u201019","volume":"29","author":"Bougakov D","year":"2020","journal-title":"Mol Neurobiol"},{"key":"e_1_2_9_48_1","first-page":"21258690","article-title":"Brain imaging before and after COVID\u201019 in UK biobank","volume":"20","author":"Douaud G","year":"2021","journal-title":"medRxiv"},{"key":"e_1_2_9_49_1","first-page":"1","article-title":"Is loss of smell an early predictor of COVID\u201019 severity: a systematic review and meta\u2010analysis","volume":"24","author":"Purja S","year":"2021","journal-title":"Arch Pharm Res"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22610"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-020-02064-9"},{"issue":"1","key":"e_1_2_9_52_1","first-page":"102796","article-title":"Relationship between disease severity and serum IL\u20106 levels in COVID\u201019 anosmia","volume":"42","author":"Sanli DET","year":"2021","journal-title":"Am J Otolaryngol \u2010 Head Neck Med Surg"},{"key":"e_1_2_9_53_1","first-page":"1","article-title":"COVID\u201019: angiotensin\u2010converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS\u2010CoV\u20102 infection","volume":"3","author":"Beyerstedt S","year":"2021","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"11","key":"e_1_2_9_54_1","first-page":"1259","article-title":"Covid\u201019: the renin\u2013angiotensin system imbalance hypothesis","volume":"134","author":"Lanza K","year":"2020","journal-title":"Clin Sci Lond Engl 1979"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006090986"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03120-0"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.27918","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.27918","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.27918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T16:27:18Z","timestamp":1692721638000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.27918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,14]]},"references-count":55,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1002\/jmv.27918"],"URL":"https:\/\/doi.org\/10.1002\/jmv.27918","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,14]]},"assertion":[{"value":"2021-11-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}