{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:18:05Z","timestamp":1787163485461,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T00:00:00Z","timestamp":1656201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Viral meningoencephalitis is one of the most important diseases that most commonly affect children. In many cases of viral meningoencephalitis, the underlying cause of the disease is not identified, raising the possibility of a variety of pathogens that are not routinely tested. Bocaviruses belong to a newly identified class of viruses that have been reported in some studies to be associated with viral encephalitis. In the present study, we investigated the prevalence of bocaviruses and other viruses in the patients suspected of having viral encephalitis and their associations with various demographic and clinical variables. Two hundred patients with suspected viral meningoencephalitis referred to Children's Medical Center were studied from 2019 to 2020. Age, sex, length of hospitalization, and course of the disease were gathered. Cerebrospinal fluid (CSF) samples were taken from the patients and subjected to biochemical examinations and PCR to identify the underlying cause. Bocaviruses were detected in none of the DNA samples extracted from the CSF specimens. The most identified organisms were mumps and enteroviruses. In 92% of cases, the underlying cause was not identified. PCR\u2010based identification of the underlying causes of viral meningoencephalitis in CSF specimens was not successful in most cases. Bocavirus was not found in any of the collected CSF samples. Further studies are required for drawing more accurate conclusions.<\/jats:p>","DOI":"10.1002\/jmv.27930","type":"journal-article","created":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T01:07:36Z","timestamp":1654909656000},"page":"4944-4949","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of human bocavirus as well as other well\u2010known viral etiologic agents by PCR in the cerebrospinal fluid of children with clinical impression of viral meningoencephalitis referred to the Children's Medical Center in Tehran, Iran, from 2019 to 2020"],"prefix":"10.1002","volume":"94","author":[{"given":"Moeinadin","family":"Safavi","sequence":"first","affiliation":[{"name":"Molecular Pathology and Cytogenetics Division, Pathology Department, Children's Medical Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5248-4495","authenticated-orcid":false,"given":"Salameh","family":"Taghipour","sequence":"additional","affiliation":[{"name":"Molecular Pathology and Cytogenetics Division, Pathology Department, Children's Medical Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Vasei","sequence":"additional","affiliation":[{"name":"Molecular Pathology and Cytogenetics Division, Pathology Department, Children's Medical Center Tehran University of Medical Sciences Tehran Iran"},{"name":"Cell\u2010based Therapies Research Center, Digestive Disease Research Institute, Shariati Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Eshaghi","sequence":"additional","affiliation":[{"name":"Department of Infectious, Diseases, Pediatric's Center of Excellence, Children's Medical, Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Taghi","family":"Haghi Ashtiani","sequence":"additional","affiliation":[{"name":"Molecular Pathology and Cytogenetics Division, Pathology Department, Children's Medical Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(05)70168-7"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.18-2-155"},{"key":"e_1_2_10_4_1","unstructured":"JamesonJL KasperDL LongoDL FauciAS HauserSL LoscalzoJ.Harrison's Principles of Internal Medicine.\u00a0McGraw Hill Professional;2018."},{"key":"e_1_2_10_5_1","unstructured":"Meningitis and encephalitis fact sheet. 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