{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T06:44:13Z","timestamp":1769150653974,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Real\u2010world data suggest\u00a0that protection against COVID\u201019 declines a few months after vaccination, particularly in the elderly and immunocompromised individuals. Our study aimed to analyze the humoral response induced by a third supplemental dose of BNT162b2 vaccine in a mixed group of immunocompromised individuals by determining anti\u2010spike (anti\u2010S) IgG antibody titers at baseline (pre\u2010third vaccine dose) and 4 weeks after the dose. Serum samples were obtained from a total group of 85 immunocompromised individuals (history of cancer: <jats:italic>n<\/jats:italic>\u2009=\u200920, lymphoma: <jats:italic>n<\/jats:italic>\u2009=\u20094, leukemia: <jats:italic>n<\/jats:italic>\u2009=\u20093, transplant recipients: <jats:italic>n<\/jats:italic>\u2009=\u20094, autoimmune disease: <jats:italic>n<\/jats:italic>\u2009=\u200942, inflammatory disease: <jats:italic>n<\/jats:italic>\u2009=\u20096, autoimmune diabetes type 1: <jats:italic>n<\/jats:italic>\u2009=\u20096) all of whom had previously received a two\u2010dose schedule of the vaccine. The average number of days between second and third dose was 139.6145 (\u00b141.39071). The overall IgG GMCs 4 weeks postvaccination were increased by more than 35 times (fold change\u2009=\u200935.30, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Fold changes were not significantly correlated with underlying condition, age, sex nor with days between second and third dose. Considering the predominance of omicron variants in the current period and the results of studies showing a decrease in the effectiveness of the third dose after 10 weeks we highly recommend a fourth dose to this vulnerable population group.<\/jats:p>","DOI":"10.1002\/jmv.27954","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T02:13:17Z","timestamp":1656036797000},"page":"5056-5060","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Antibody titers after a third dose of the SARS\u2010CoV\u20102 BNT162b2 vaccine in immunocompromised adults in Greece: Is a fourth dose necessary?"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0121-8688","authenticated-orcid":false,"given":"Konstantina","family":"Kontopoulou","sequence":"first","affiliation":[{"name":"Laboratory of Microbiology \u201cG. Gennimatas\u201d General Hospital Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4155-722X","authenticated-orcid":false,"given":"Christos T.","family":"Nakas","sequence":"additional","affiliation":[{"name":"Laboratory of Biometry University of Thessaly Nea Ionia\/Volos, Magnesia Greece"},{"name":"University Institute of Clinical Chemistry, Inselspital, Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chrysoula","family":"Belai","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology \u201cG. Gennimatas\u201d General Hospital Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1641-9095","authenticated-orcid":false,"given":"Georgios","family":"Papazisis","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, School of Medicine Aristotle University of Thessaloniki Thessaloniki Greece"},{"name":"Clinical Research Unit, Special Unit for Biomedical Research and Education, School of Medicine Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00947-8"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2114583"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/M21-1757"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-0959-x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiab075"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41928"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2021.06.036"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2021.08.005"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2021.11.006"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2021.12.014"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021014085"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2108861"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/ti.2022.10239"},{"key":"e_1_2_11_15_1","first-page":"10","article-title":"Better outcomes of COVID\u201019 in vaccinated compared to unvaccinated patients with systemic rheumatic diseases","volume":"8","author":"Papagoras C","year":"2022","journal-title":"Ann\u00a0Rheum Dis"},{"key":"e_1_2_11_16_1","doi-asserted-by":"crossref","first-page":"e069989","DOI":"10.1136\/bmj-2022-069989","article-title":"Effectiveness of heterologous and homologous covid\u201019 vaccine regimens: living systematic review with network meta\u2010analysis","volume":"377","author":"Au WY","year":"2022","journal-title":"BMJ"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27516"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2119451"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.o30"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-220272"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2201570"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.27954","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.27954","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.27954","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T16:30:24Z","timestamp":1692721824000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.27954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1002\/jmv.27954"],"URL":"https:\/\/doi.org\/10.1002\/jmv.27954","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"2022-06-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}