{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:31:53Z","timestamp":1773016313156,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T00:00:00Z","timestamp":1656720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100013059","name":"Jiangsu Provincial Medical Youth Talent","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013059","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Early diagnosis and prognosis evaluation are of great significance to hepatitis E virus\u00a0(HEV)\u2010related acute liver failure (HEV\u2010ALF) patients. We collected serum samples from 200 health controls (HCs), 200 patients with acute hepatitis E (AHE), and 200 HEV\u2010ALF patients to evaluate serum exosome\u2010derived carbamoyl phosphate synthase 1 (CPS1) levels and determine its diagnostic and prognostic value. The exosome\u2010derived CPS1 levels in the HEV\u2010ALF group were significantly higher than those in the AHE and HCs groups. The AUC of exosome\u2010derived CPS1 to predict the occurrence of HEV\u2010ALF was 0.850 (0.811\u22120.883). Both logistical regression and orthogonal partial least squares discriminant analysis (OPLS\u2010DA) showed that exosome\u2010derived CPS1 is an independent risk factor for HEV\u2010ALF. The exosome\u2010derived CPS1 levels were positively correlated with organ failure\u00a0and the outcomes in HEV\u2010ALF patients. The exosome\u2010derived CPS1 levels in the worsening group were significantly higher than those in the fluctuating and the improving groups. The AUC of serum exosome\u2010derived CPS1 to predict 30\u2010day mortality was 0.829 (0.770\u22120.879), which was significantly greater than that of the Child\u2010Pugh, KCH, and MELD models. The level of serum exosome\u2010derived CPS1 might serve as a promising diagnostic and prognostic biomarker for HEV\u2010ALF patients, which may provide better guidance for the diagnosis, prognosis, and treatment of HEV\u2010ALF patients.<\/jats:p>","DOI":"10.1002\/jmv.27961","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T02:04:35Z","timestamp":1656381875000},"page":"5015-5025","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The diagnostic and prognostic value of serum exosome\u2010derived carbamoyl phosphate synthase 1 in HEV\u2010related acute liver failure patients"],"prefix":"10.1002","volume":"94","author":[{"given":"Ze","family":"Xiang","sequence":"first","affiliation":[{"name":"Zhejiang University School of Medicine Hangzhou Zhejiang 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