{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T08:11:36Z","timestamp":1787991096730,"version":"build-2784847793"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:00:00Z","timestamp":1657670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The impact of long\u2010term nucleos(t)ide analogs treatment on host metabolism is a concern. Hence, we conducted this study to compare the effect of entecavir (ETV) and tenofovir disoproxil fumarate (TDF) on metabolic parameters among chronic hepatitis B\u00a0(CHB) patients.\u00a0In this real\u2010life retrospective study, 2030 CHB outpatients treated with ETV or TDF at Nanfang Hospital, China, were included. For treatment\u2010na\u00efve patients, pretreatment and semiannual metabolic parameters were collected. For treatment\u2010experienced patients, metabolic parameters were collected at the first visit. Propensity score matching (PSM) was used to balance the effects of potential confounding factors.\u00a0Among 122 treatment\u2010na\u00efve patients and 1908 treatment\u2010experienced patients, ETV\u2010treated patients were older with a higher percentage of metabolic syndrome. After PSM, the characteristics were comparable between the two groups. For treatment\u2010na\u00efve patients, four lipid parameters, including total cholesterol (TC), low\u2010density lipoprotein (LDL), high\u2010density lipoprotein, and triglyceride levels showed a decreasing trend during the 42\u2010month TDF treatment, while they remained relatively stable or increased during ETV treatment. At Month 30, the levels of TC and LDL among TDF\u2010treated patients were significantly lower than those among ETV\u2010treated patients (TC: 4.7\u2009mmol\/L vs. 3.9\u2009mmol\/L, <jats:italic>p<\/jats:italic>\u2009=\u20090.004; LDL: 3.0\u2009mmol\/L vs. 2.4\u2009mmol\/L, <jats:italic>p<\/jats:italic>\u2009=\u20090.009). For treatment\u2010experienced patients, we also observed lower levels of lipid parameters in patients with different durations of TDF treatment. The levels of glucose and uric acid were similar among ETV\u2010 and TDF\u2010treated patients.\u00a0TDF has a lipid\u2010lowering effect in CHB patients, which provides a basis for the selection of antiviral drugs for aging CHB patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.27977","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T01:54:20Z","timestamp":1657158860000},"page":"5465-5474","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Real\u2010life impact of tenofovir disoproxil fumarate and entecavir therapy on lipid profile, glucose, and uric acid in chronic hepatitis B patients"],"prefix":"10.1002","volume":"94","author":[{"given":"Qi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Hepatology Unit, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Nanfang 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