{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:18:26Z","timestamp":1792685906695,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T00:00:00Z","timestamp":1659139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2017J01232"],"award-info":[{"award-number":["2017J01232"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    There is evidence that coinfection of cervicovaginal high\u2010risk human papillomavirus (HR\u2010HPV) and bacteria is common in women of childbearing age. However, the relationship between bacterial vaginosis (BV) and persistent HR\u2010HPV infection in women of childbearing age and the underlying mechanisms remain unclear. In this study, we determined whether BV affects persistent HR\u2010HPV infection in women aged 20\u201345 years and explored the possible mechanisms of their interactions. From January 1 to April 30, 2020, we recruited women aged 20\u201345 years with and without BV at a ratio of 1:2 from Fujian Maternity\u00a0and Child Health Hospital. All women were followed up\u00a0at 0, 12, and 24 months. A BV assay, HR\u2010HPV genotyping and cervical cytology were performed at each follow\u2010up. At 0 months, additional vaginal secretions and cervical exfoliated cells were collected for 16S\u00a0ribosomal RNA\u00a0sequencing, bacterial metabolite determination, and\n                    <jats:italic>POU5F1B<\/jats:italic>\n                    ,\n                    <jats:italic>C\u2010myc<\/jats:italic>\n                    ,\n                    <jats:italic>TLR4<\/jats:italic>\n                    ,\n                    <jats:italic>NF\u2010\u03baB<\/jats:italic>\n                    , and\n                    <jats:italic>hTERT<\/jats:italic>\n                    quantification. A total of 920 women were included. The abundance of\n                    <jats:italic>Prevotella<\/jats:italic>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.016) and\n                    <jats:italic>Gardnerella<\/jats:italic>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.027) were higher, whereas the abundance of\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    was lower (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001) in women with persistent HR\u2010HPV infection and high\u2010grade squamous intraepithelial lesions (HSIL). The abundance of\n                    <jats:italic>Prevotella<\/jats:italic>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.025) and\n                    <jats:italic>Gardnerella<\/jats:italic>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.018) increased in the vaginas of women with persistent HPV16 infection, whereas only the abundance of\n                    <jats:italic>Prevotella<\/jats:italic>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.026) was increased in women with persistent HPV18 infection. The abundance of\n                    <jats:italic>Prevotella<\/jats:italic>\n                    in the vagina was significantly positively correlated with the expression levels of\n                    <jats:italic>TLR4<\/jats:italic>\n                    ,\n                    <jats:italic>NF\u2010\u03baB<\/jats:italic>\n                    ,\n                    <jats:italic>C\u2010myc<\/jats:italic>\n                    , and\n                    <jats:italic>hTERT<\/jats:italic>\n                    in host cervical cells (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Our findings suggest that overgrowth of\n                    <jats:italic>Prevotella<\/jats:italic>\n                    in the vagina may influence the occurrence of persistent HR\u2010HPV infection\u2010related cervical lesions through host\n                    <jats:italic>NF\u2010\u03baB<\/jats:italic>\n                    and\n                    <jats:italic>C\u2010myc<\/jats:italic>\n                    signaling.\n                  <\/jats:p>","DOI":"10.1002\/jmv.28001","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T22:13:34Z","timestamp":1657836814000},"page":"5519-5534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["<i>Prevotella<\/i>\n                    as the hub of the cervicovaginal microbiota affects the occurrence of persistent human papillomavirus infection and cervical lesions in women of childbearing age via host\n                    <i>NF\u2010\u03baB<\/i>\n                    \/\n                    <i>C\u2010myc<\/i>"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5086-0696","authenticated-orcid":false,"given":"Binhua","family":"Dong","sequence":"first","affiliation":[{"name":"Laboratory of Gynecologic Oncology, Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics Fujian Medical University  Fuzhou Fujian People's Republic of China"},{"name":"Fujian Key Laboratory of Women and Children's Critical Diseases Research  Fuzhou Fujian People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Laboratory of Gynecologic Oncology, Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics Fujian Medical University  Fuzhou Fujian People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4700-2754","authenticated-orcid":false,"given":"Hongning","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Gynecology Maternal and Child Health Hospital of Hubei Province (Women and Children's Hospital of Hubei Province) Wuhan Hubei People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaojia","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory of Gynecologic Oncology, Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics Fujian Medical University  Fuzhou Fujian People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of Gynecologic Oncology, Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics Fujian Medical University  Fuzhou Fujian People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8161-7576","authenticated-orcid":false,"given":"Huachun","family":"Zou","sequence":"additional","affiliation":[{"name":"School of Public Health (Shenzhen) Sun Yat\u2010sen University Shenzhen People's Republic of China"},{"name":"Kirby Institute University of New South Wales  New South Wales Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyu","family":"Lin","sequence":"additional","affiliation":[{"name":"Laboratory of Gynecologic Oncology, Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics Fujian Medical University  Fuzhou Fujian People's Republic of 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5072-6091","authenticated-orcid":false,"given":"Pengming","family":"Sun","sequence":"additional","affiliation":[{"name":"Laboratory of Gynecologic Oncology, Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics Fujian Medical University  Fuzhou Fujian People's Republic of China"},{"name":"Fujian Key Laboratory of Women and Children's Critical Diseases Research  Fuzhou Fujian People's Republic of 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