{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T11:15:58Z","timestamp":1756898158133,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To investigate a 12\u2010year historical series (2006\u20132017) of human T\u2010cell lymphotropic virus (HTLV)\u2010positive blood donations from Funda\u00e7\u00e3o Hemominas, Minas Gerais, Brazil, an observational retrospective study was performed to evaluate data of blood donor candidates who were screened for HTLV\u20101\/2 by enzyme\u2010linked immunosorbent assay or chemiluminescence assays and confirmed by Western blot. We analyzed 3\u2009309\u2009716 blood donations covering 2006\u20132017 that were extracted from the institutional database. In a total of 3\u2009308\u2009738 donations that have complete algorithm tests, the global frequency of HTLV\u2010positive donations was 0.012%. The seroprevalence in first\u2010time blood donors was 28.82\/100\u2009000 donors; 0.95\/100\u2009000 donations were HTLV\u2010positive in repeat blood donors. The frequency of HTLV\u2010seropositive females was significantly higher than males\u00a0(odds ratio\u2009=\u20091.85, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) in first\u2010time donors. The median age of HTLV\u2010positive first\u2010time and repeat donors was similar (36 and 32 years, respectively). First\u2010time donors \u226541 years had higher odds to be infected. There was a clear tendency of decline in the HTLV\u2010positive donations in the period analyzed, going from 19.26\/100\u2009000 donations to 8.50\/100\u2009000 donations. The increase in the proportion of repeat donors over the period analyzed (from 23% in 2006 to 67% in 2017) must be the principal factor that contributed to this drop. Our results showed a continuous decline in the frequency of HTLV\u2010positive donations from Minas Gerais, Brazil throughout 12 years and emphasize the importance of having a high rate of repeat donors in blood centers to reduce the residual risk of transfusion\u2010transmitted infections.<\/jats:p>","DOI":"10.1002\/jmv.28010","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T06:18:29Z","timestamp":1658297909000},"page":"5535-5542","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Decline in human T\u2010cell lymphotropic virus seroprevalence in blood donors from Minas Gerais, Brazil over a\u00a012\u2010year period (2006\u20132017)"],"prefix":"10.1002","volume":"94","author":[{"given":"Maria Clara\u00a0Fernandes","family":"da Silva Malta","sequence":"first","affiliation":[{"name":"Servi\u00e7o de Pesquisa Funda\u00e7\u00e3o Hemominas Belo Horizonte Minas Gerais 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