{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:12:45Z","timestamp":1772118765987,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T00:00:00Z","timestamp":1659139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study assessed T\u2010cell responses in individuals with and without a positive antibody response to SARS\u2010CoV\u20102, in symptomatic and asymptomatic individuals during the COVID\u201019 pandemic. Participants were drawn from the TwinsUK cohort, grouped by (a) presence or absence of COVID\u2010associated symptoms (S+, S\u2212), logged prospectively through the COVID Symptom Study app, and (b) anti\u2010IgG Spike and anti\u2010IgG Nucleocapsid antibodies measured by ELISA (Ab+, Ab\u2212), during the first wave of the UK pandemic. T\u2010cell helper and regulatory responses after stimulation with SARS\u2010CoV\u20102 peptides were assessed. Thirty\u2010two participants were included in the final analysis. Fourteen of 15 with IgG Spike antibodies had a T\u2010cell response to SARS\u2010CoV\u20102\u2010specific peptides; none of 17 participants without IgG Spike antibodies had a T\u2010cell response (\n                    <jats:italic>\u03c7<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    : 28.2,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Quantitative T\u2010cell responses correlated strongly with fold\u2010change in IgG Spike antibody titer\u00a0(\n                    <jats:italic>\u03c1<\/jats:italic>\n                    \u2009=\u20090.79,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001) but not to symptom score (\n                    <jats:italic>\u03c1<\/jats:italic>\n                    \u2009=\u20090.17,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.35). Humoral and cellular immune responses to SARS\u2010CoV\u20102 are highly correlated. We found no evidence of cellular immunity suggestive of SARS\u2010CoV2 infection in individuals with a COVID\u201019\u2010like illness but negative antibodies.\n                  <\/jats:p>","DOI":"10.1002\/jmv.28016","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T23:49:38Z","timestamp":1658447378000},"page":"5217-5224","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Concordance of B\u2010 and T\u2010cell responses to SARS\u2010CoV\u20102 infection, irrespective of symptoms suggestive of COVID\u201019"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7363-5574","authenticated-orcid":false,"given":"Marc F.","family":"\u00d6sterdahl","sequence":"first","affiliation":[{"name":"Department of Twin Research &amp; Genetic Epidemiology, School of Life Course Sciences, Faculty of Life Sciences and Medicine King's College London  London UK"},{"name":"Department of Ageing and Health Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleni","family":"Christakou","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, School of Immunology &amp; Microbial Sciences King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Hart","sequence":"additional","affiliation":[{"name":"Department of Twin Research &amp; Genetic Epidemiology, School of Life Course Sciences, Faculty of Life Sciences and Medicine King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ffion","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, School of Immunology &amp; Microbial Sciences King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasaman","family":"Shahrabi","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, School of Immunology &amp; Microbial Sciences King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Pollock","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, School of Immunology &amp; Microbial Sciences King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muntaha","family":"Wadud","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, School of Immunology &amp; Microbial Sciences King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim D.","family":"Spector","sequence":"additional","affiliation":[{"name":"Department of Twin Research &amp; Genetic Epidemiology, School of Life Course Sciences, Faculty of Life Sciences and Medicine King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew A.","family":"Brown","sequence":"additional","affiliation":[{"name":"Guy's and St Thomas' NHS Foundation Trust and King's College London NIHR Biomedical Research Centre King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Seow","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, School of Immunology &amp; Microbial Sciences King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael H.","family":"Malim","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, School of Immunology &amp; Microbial Sciences King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire J.","family":"Steves","sequence":"additional","affiliation":[{"name":"Department of Twin Research &amp; Genetic Epidemiology, School of Life Course Sciences, Faculty of Life Sciences and Medicine King's College London  London UK"},{"name":"Department of Ageing and Health Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie J.","family":"Doores","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, School of Immunology &amp; Microbial Sciences King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma L.","family":"Duncan","sequence":"additional","affiliation":[{"name":"Department of Twin Research &amp; Genetic Epidemiology, School of Life Course Sciences, Faculty of Life Sciences and Medicine King's College London  London UK"},{"name":"Department of Endocrinology Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Tree","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, School of Immunology &amp; Microbial Sciences King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,30]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"WHO. WHO Coronavirus (COVID\u201019) Dashboard. Accessed July 31 \u00a02021.https:\/\/covid19.who.int\/"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2034577"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21336-8"},{"key":"e_1_2_11_5_1","volume-title":"Molecular Biology of the Cell","author":"Alberts B","year":"2002"},{"key":"e_1_2_11_6_1","first-page":"15","article-title":"Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS\u2010CoV\u20102 infection","volume":"3698","author":"Reynolds CJ","year":"2020","journal-title":"Sci Immunol"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.10.011"},{"key":"e_1_2_11_8_1","unstructured":"Public Health England.PHE National Influenza Report: Week 12.London UK.\u00a0Accessed July 31 2021.https:\/\/assets.publishing.service.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/873734\/National_influenze_report_19_March_2020_week_12.pdf"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc070348"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2550-z"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/thg.2019.65"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.16671.1"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0916-2"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008817"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201090"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.1"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201344381"},{"issue":"6","key":"e_1_2_11_18_1","first-page":"746","article-title":"Durability of neutralizing antibodies and T\u2010cell response post SARS\u2010CoV\u20102","volume":"14","author":"Lin Y","year":"2020","journal-title":"Infection"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.08.017"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2701.203611"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2598-9"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf4063"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.28016","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.28016","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.28016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T01:26:58Z","timestamp":1692754018000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.28016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,30]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1002\/jmv.28016"],"URL":"https:\/\/doi.org\/10.1002\/jmv.28016","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.02.03.22270393","asserted-by":"object"}]},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,30]]},"assertion":[{"value":"2022-03-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}