{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:13:26Z","timestamp":1772118806160,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To assess the genetic diversity of circulating dengue virus 2 (DENV\u20102) in Senegal, we analyzed nine newly generated complete genomes of strains isolated during the 2018 outbreaks and 06 sequences obtained in 2018 and 2019 from Thi\u00e8s and Rosso, respectively. Phylogenetic analyses revealed that Senegalese strains belonged to the cosmopolitan genotype of DENV\u20102, but we observed intragenotype variability leading to a divergence in two clades associated with specific geographic distribution. We report two DENV\u20102 variants belonging to two distinct clades. Isolates from the \u201cNorthern clade\u201d (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20098) harbored three nonsynonymous mutations (V1183M, R1405K, P2266T) located respectively on NS2A, NS2B, and NS4A, while isolates from the \u201cWestern clade\u201d (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20097) had two nonsynonymous mutations (V1185E, V3214E) located respectively in the NS2A and NS5 genes. These findings call for phylogeographic analysis to investigate routes of introductions, dispersal patterns,\u00a0and in\u2010depth in vitro and functional study to elucidate the impact of observed mutations on viral fitness, spread, epidemiology, and pathology.\n                  <\/jats:p>","DOI":"10.1002\/jmv.28027","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:33:39Z","timestamp":1658795619000},"page":"5593-5600","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Full genome analysis of circulating DENV\u20102 in Senegal reveals a regional diversification into separate clades"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8584-5592","authenticated-orcid":false,"given":"Idrissa","family":"Dieng","sequence":"first","affiliation":[{"name":"Virology Department, Arboviruses and Haemorrhagic Fever Viruses Unit Institut Pasteur de Dakar Dakar Senegal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amadou","family":"Diallo","sequence":"additional","affiliation":[{"name":"Epidemiology, Clinical Research and Data Science Department Institut Pasteur de Dakar Dakar Senegal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mignane","family":"Ndiaye","sequence":"additional","affiliation":[{"name":"Virology Department, Arboviruses and Haemorrhagic Fever Viruses Unit Institut Pasteur de Dakar Dakar Senegal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moufid","family":"Mhamadi","sequence":"additional","affiliation":[{"name":"Virology Department, Arboviruses and Haemorrhagic Fever Viruses Unit Institut Pasteur de Dakar Dakar Senegal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moussa Mo\u00efse","family":"Diagne","sequence":"additional","affiliation":[{"name":"Virology Department, Arboviruses and Haemorrhagic Fever Viruses Unit Institut Pasteur de Dakar Dakar Senegal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safietou","family":"Sankhe","sequence":"additional","affiliation":[{"name":"Virology Department, Arboviruses and Haemorrhagic Fever Viruses Unit Institut Pasteur de Dakar Dakar Senegal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie Henriette Dior","family":"Ndione","sequence":"additional","affiliation":[{"name":"Virology Department, Arboviruses and Haemorrhagic Fever Viruses Unit Institut Pasteur de Dakar Dakar Senegal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aboubacry","family":"Gaye","sequence":"additional","affiliation":[{"name":"Epidemiology, Clinical Research and Data Science Department Institut Pasteur de Dakar Dakar Senegal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samba Niang","family":"Sagne","sequence":"additional","affiliation":[{"name":"Epidemiology, Clinical Research and Data Science Department Institut Pasteur de Dakar Dakar Senegal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1107-0859","authenticated-orcid":false,"given":"Jean Michel","family":"Heraud","sequence":"additional","affiliation":[{"name":"Virology Department, Arboviruses and Haemorrhagic Fever Viruses Unit Institut Pasteur de Dakar Dakar Senegal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amadou Alpha","family":"Sall","sequence":"additional","affiliation":[{"name":"Virology Department, Arboviruses and Haemorrhagic Fever Viruses Unit Institut Pasteur de Dakar Dakar Senegal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamou","family":"Fall","sequence":"additional","affiliation":[{"name":"Virology Department, Arboviruses and Haemorrhagic Fever Viruses Unit Institut Pasteur de Dakar Dakar Senegal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheikh","family":"Loucoubar","sequence":"additional","affiliation":[{"name":"Virology Department, Arboviruses and Haemorrhagic Fever Viruses Unit Institut Pasteur de Dakar Dakar Senegal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ousmane","family":"Faye","sequence":"additional","affiliation":[{"name":"Virology Department, Arboviruses and Haemorrhagic Fever Viruses Unit Institut Pasteur de Dakar Dakar Senegal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oumar","family":"Faye","sequence":"additional","affiliation":[{"name":"Virology Department, Arboviruses and Haemorrhagic Fever Viruses Unit Institut Pasteur de Dakar Dakar Senegal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,5]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Global Strategy for Dengue Prevention and Control, 2012\u20102020. 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