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This study evaluated antibody response after the second dose of the COVID\u201019 vaccine in the Children's Medical Center personnel. The blood samples of 174 healthcare workers were gathered at least 10 days after vaccination. The administered vaccines included Oxford\/AstraZeneca, COVAXIN, Sinopharm, and Sputnik V. This study assessed all antibodies employing ELISA methods, including anti\u2010SARS\u2010CoV\u20102 neutralizing antibody by DiaZist and Pishtazteb kits, anti\u2010SARS\u2010CoV\u20102\u2010nucleocapsid by Pishtazteb kit, and anti\u2010SARS\u2010CoV\u20102\u2010Spike by Razi kit. The cutoff for the tests' results was calculated according to the instructions of each kit. Totally, 174 individuals with an average age of 40\u2009\u00b1\u20099 years participated in this study, the proportion of men was 31%, and the frequency of past COVID\u201019 infection was 66 (38%). Sixteen (9%) personnel received Oxford\/AstraZeneca, 28 (16%) COVAXIN, 29 (17%) Sinopharm, and 101 (58%) Sputnik V. anti\u2010SARS\u2010CoV\u20102\u2010nucleocapsid and anti\u2010SARS\u2010CoV\u20102\u2010Spike were positive in 37 (21%), and 163 (94%) participants and their mean level were more in adenoviral\u2010vectored vaccines (<jats:italic>p<\/jats:italic> value\u2009&lt;\u20090.0001). Neutralizing antibody was positive in 74% using Pishtazteb kit while 87% using DiaZist kit. All antibodies' levels were significantly higher in those with a past COVID\u201019 infection (<jats:italic>p<\/jats:italic> value\u2009&lt;\u20090.0001). In conclusion, Oxford\/AstraZeneca and Sputnik V had a similar outcome of inducing high levels of anti\u2010SARS\u2010Cov\u20102\u2010spike and neutralizing antibodies, which were more than Sinopharm and COVAXIN. The titers of Anti\u2010SARS\u2010CoV\u20102\u2010nucleocapsid antibody were low in all of these four vaccines.<\/jats:p>","DOI":"10.1002\/jmv.28029","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T03:34:36Z","timestamp":1658892876000},"page":"5669-5677","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of response to different COVID\u201019 vaccines in vaccinated healthcare workers in a single center in Iran"],"prefix":"10.1002","volume":"94","author":[{"given":"Babak","family":"Pourakbari","sequence":"first","affiliation":[{"name":"Pediatric Infectious Diseases Research Center Tehran University of Medical Sciences  Tehran Iran"},{"name":"Pediatrics Center of Excellence, Children's Medical Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona","family":"Mirbeyk","sequence":"additional","affiliation":[{"name":"Research Center for Immunodeficiencies, Children's Medical Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3557-6432","authenticated-orcid":false,"given":"Shima","family":"Mahmoudi","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases Research Center Tehran University of Medical Sciences  Tehran Iran"},{"name":"Pediatrics Center of Excellence, Children's Medical Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reihaneh H.","family":"Hosseinpour Sadeghi","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3836-1827","authenticated-orcid":false,"given":"Nima","family":"Rezaei","sequence":"additional","affiliation":[{"name":"Research Center for Immunodeficiencies, Children's Medical Center Tehran University of Medical Sciences  Tehran Iran"},{"name":"Division of Medical Research, Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA) Universal Scientific Education and Research Network (USERN)  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raheleh","family":"Ghasemi","sequence":"additional","affiliation":[{"name":"Pediatrics Center of Excellence, Children's Medical Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Esfandiari","sequence":"additional","affiliation":[{"name":"Pediatrics Center of Excellence, Children's Medical Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8851-3622","authenticated-orcid":false,"given":"Setareh","family":"Mamishi","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases Research Center Tehran University of Medical Sciences  Tehran Iran"},{"name":"Department of Infectious Diseases, Pediatrics Center of Excellence, Children's Medical Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens9030231"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30079-5"},{"key":"e_1_2_11_5_1","unstructured":"WHO. 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