{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:25:44Z","timestamp":1789381544387,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T00:00:00Z","timestamp":1659744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T00:00:00Z","timestamp":1659744000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Monkeypox virus (MPXV) has generally circulated in West and Central Africa since its emergence. Recently, sporadic MPXV infections in several nonendemic countries have attracted widespread attention. Here, we conducted a systematic analysis of the recent outbreak of MPXV\u20102022, including its genomic annotation and molecular evolution. The phylogenetic analysis indicated that the MPXV\u20102022 strains belong to the same lineage of the MPXV strain isolated in 2018. However, compared with the MPXV strain in 2018, in total 46 new consensus mutations were observed in the MPXV\u20102022 strains, including 24 nonsynonymous mutations. By assigning mutations to 187 proteins encoded by the MPXV genome, we found that 10 proteins in the MPXV are more prone to mutation, including D2L\u2010like, OPG023, OPG047, OPG071, OPG105, OPG109, A27L\u2010like, OPG153, OPG188, and OPG210 proteins. In the MPXV\u20102022 strains, four and three nucleotide substitutions are observed in OPG105 and OPG210, respectively. Overall, our studies illustrated the genome evolution of the ongoing MPXV outbreak and pointed out novel mutations as a reference for further studies.<\/jats:p>","DOI":"10.1002\/jmv.28036","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T22:33:35Z","timestamp":1659134015000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":147,"title":["Genomic annotation and molecular evolution of monkeypox virus outbreak in 2022"],"prefix":"10.1002","volume":"95","author":[{"given":"Lulan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics University of California, Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingzhe","family":"Shang","sequence":"additional","affiliation":[{"name":"Institute of Systems Medicine Chinese Academy of Medical Sciences &amp; Peking Union Medical College Beijing China"},{"name":"Suzhou Institute of Systems Medicine Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghui","family":"Weng","sequence":"additional","affiliation":[{"name":"Institute of Systems Medicine Chinese Academy of Medical Sciences &amp; Peking Union Medical College Beijing China"},{"name":"Suzhou Institute of Systems Medicine Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saba R.","family":"Aliyari","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics University of California, Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyang","family":"Ji","sequence":"additional","affiliation":[{"name":"Institute of Systems Medicine Chinese Academy of Medical Sciences &amp; Peking Union Medical College Beijing China"},{"name":"Suzhou Institute of Systems Medicine Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6713-2783","authenticated-orcid":false,"given":"Genhong","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics University of California, Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiping","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Systems Medicine Chinese Academy of Medical Sciences &amp; Peking Union Medical College Beijing China"},{"name":"Suzhou Institute of Systems Medicine Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit703"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01254676"},{"issue":"5","key":"e_1_2_9_4_1","first-page":"593","article-title":"A human infection caused by monkeypox virus in Basankusu Territory, Democratic Republic of the Congo","volume":"46","author":"Ladnyj I","year":"1972","journal-title":"Bull World Health Organ"},{"issue":"23","key":"e_1_2_9_5_1","first-page":"537","article-title":"Multistate outbreak of monkeypox\u2014Illinois, Indiana, and Wisconsin, 2003","volume":"52","author":"Control CfD, Prevention","year":"2003","journal-title":"MMWR Morb Mort\u00a0Wkly Rep"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/v12111257"},{"key":"e_1_2_9_7_1","unstructured":"WHO. Disease outbreak news; multi\u2010country monkeypox outbreak in non\u2010endemic countries. 2022. Accessed May 29 2022.https:\/\/wwwwhoint\/emergencies\/disease-outbreak-news\/item\/2022-DON388"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","unstructured":"team Gh.Monkeypox 2022 global epidemiology.2022. Accessed July 15 2022.\u00a0https:\/\/wwwmonkeypoxglobalhealth\/","DOI":"10.1097\/01.NURSE.0000891948.41298.22"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2006.01.016"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2002.1446"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.19565-0"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11262-010-0560-x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1125134"},{"key":"e_1_2_9_14_1","unstructured":"nextstrain. monkeypox\u2010nextstrain. 2022. 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