{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T20:39:50Z","timestamp":1782419990160,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007693","name":"King Chulalongkorn Memorial Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007693","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The coronavirus 2019 omicron variant has surged rapidly and raises concerns about immune evasion even in individuals with complete vaccination, because it harbors mutations. Here we examine the capability of booster vaccination following CoronaVac\/AZD1222 prime to induce neutralizing antibodies (NAbs) against omicron (BA.1 and BA.2) and T\u2010cell responses. A total of 167 participants primed with heterologous CoronaVac\/AZD1222 for 4\u20135 months were enrolled, to receive AZD1222, BNT162b2, or mRNA\u20101273 as a third dose. Reactogenicity was recorded. Immunogenicity analyses of severe acute respiratory syndrome coronavirus 2\u2010binding antibodies were measured using enzyme\u2010linked immunosorbent assay. The NAb titers against omicron BA.1 and BA.2 were determined using the focus reduction neutralization test (FRNT50) and total interferon\u2010\u03b3 responses were measured to observe the T\u2010cell activation. A substantial loss in neutralizing potency to omicron variant was found at 4\u20135 months after receiving the heterologous CoronaVac\/AZD1222. Following booster vaccination, a significant increase in binding antibodies and neutralizing activities toward delta and omicron variants was observed. Neutralization to omicron BA.1 and BA.2 were comparable, showing the highest titers after boosted mRNA\u20101273 followed by BNT162b2 and AZD1222. In addition, individuals boosted with messenger RNA (mRNA) vaccines develop a T\u2010cell response to spike protein, whereas those boosted with AZD1222 did not. Reactogenicity was mild to moderate without serious adverse events. Our findings demonstrated that mRNA booster vaccination is able to overcome waning immunity to provide antibodies that neutralize omicron BA.1 and BA.2, as well as a T\u2010cell response.<\/jats:p>","DOI":"10.1002\/jmv.28044","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T04:31:18Z","timestamp":1659587478000},"page":"5713-5722","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Effects of boosted mRNA and adenoviral\u2010vectored vaccines on immune responses to omicron BA.1 and BA.2 following the heterologous CoronaVac\/AZD1222 vaccination"],"prefix":"10.1002","volume":"94","author":[{"given":"Nungruthai","family":"Suntronwong","sequence":"first","affiliation":[{"name":"Center of Excellence in Clinical Virology, Faculty of Medicine Chulalongkorn University Bangkok 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Osteoarthritis and Musculoskeleton, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital Thai Red Cross Society Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanunrat","family":"Thongmee","sequence":"additional","affiliation":[{"name":"Center of Excellence in Clinical Virology, Faculty of Medicine Chulalongkorn University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeyaporn","family":"Vichaiwattana","sequence":"additional","affiliation":[{"name":"Center of Excellence in Clinical Virology, Faculty of Medicine Chulalongkorn University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaneeya","family":"Duangchinda","sequence":"additional","affiliation":[{"name":"Molecular Biology of Dengue and Flaviviruses Research Team, National Center for Genetic Engineering and Biotechnology (BIOTEC) National Science and Development Agency, NSTDA Pathum Thani 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