{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T01:07:07Z","timestamp":1775092027077,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The seroprevalence of Kaposi's sarcoma\u2010associated herpesvirus (KSHV) is high in Xinjiang, China. But the seroprevalence of KSHV and risk factors are still unknown in Gansu which is adjacent to Xinjiang.\u00a0Six hundred and seventy\u2010eight\u00a0serum samples of the general population and 87 serum samples of syphilis patients from Jiuquan, Gansu were tested for antibodies against KSHV, including one latent protein (ORF73) and two lytic proteins (ORF65 and K8.1) using the ELISA. The total KSHV\u2010seropositive rate was 15.9% in 678 serum samples in the Jiuquan area, and the KSHV\u2010seropositive rate of males was higher than females (18.0% vs. 14.6%, <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). The Uygur, Kazakh, Hui, Manchu, and Mongolian populations had a higher seroprevalence of KSHV than the Han population (43.8%, 40.0%, 34.5%, 30.3%, 35.0% vs. 11.0%, respectively) among the ethnic groups in Jiuquan. Compared to the Han, Uygur, Kazak, Hui, Manchu, and Mongolian people had an increase in the risk of KSHV of 528.9%, 439.1%, 325.6%, 251.6%, and 335.4% (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>p<\/jats:italic>\u2009=\u20090.002, <jats:italic>p<\/jats:italic>\u2009=\u20090.003, respectively). The serum prevalence of KSHV in subjects aged\u2009&lt;\u200920 years, 20\u221250 years, and &gt;50 years was 13.8%, 14.7%, and 20.1%, respectively. Compared to the subjects aged\u2009&lt;\u200920 years, 20\u221250 years and &gt;50 years had an increase in the risk of KSHV of 7.4% and 56.9% (<jats:italic>p<\/jats:italic>\u2009=\u20090.829 and <jats:italic>p<\/jats:italic>\u2009=\u20090.204, respectively). Compared to the positive rate of KSHV in the general population of Anhui, the positive rate of KSHV was significantly higher in the general population of the Jiuquan area (15.9% vs. 9%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). There was no significant difference in the positive rate of KSHV between the Han population of Jiuquan and the Han population of Anhui (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). In the population of syphilis patients in the Jiuquan area, the positive rate of KSHV was 30.7%, which was higher than that of the general population in the Gansu area (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). This study indicates that Gansu has a high seroprevalence of KSHV. Ethnicity and syphilis are risk factors for KSHV infection.<\/jats:p>","DOI":"10.1002\/jmv.28045","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T02:19:23Z","timestamp":1659579563000},"page":"6016-6022","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Seroprevalence of Kaposi's sarcoma\u2010associated herpesvirus and risk factors in Jiuquan area, China"],"prefix":"10.1002","volume":"94","author":[{"given":"Yuan","family":"Fang","sequence":"first","affiliation":[{"name":"Blood Transfusion Department Anhui No. 2 Provincial People's Hospital Hefei Anhui China"},{"name":"Department of Microbiology and Parasitology, The Key Laboratory of Microbiology and Parasitology of Anhui Province, The Key Laboratory of Zoonoses of High Institutions in Anhui, School of Basic Medical Sciences Anhui Medical University Hefei Anhui 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University Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanwu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, The Key Laboratory of Microbiology and Parasitology of Anhui Province, The Key Laboratory of Zoonoses of High Institutions in Anhui, School of Basic Medical Sciences Anhui Medical University Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, The Key Laboratory of Microbiology and Parasitology of Anhui Province, The Key Laboratory of Zoonoses of High Institutions in Anhui, School of Basic Medical Sciences Anhui Medical University Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Dai","sequence":"additional","affiliation":[{"name":"Second Clinical Medical College Anhui Medical University 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