{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T08:28:31Z","timestamp":1751617711550,"version":"3.37.3"},"reference-count":12,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T00:00:00Z","timestamp":1660521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Various variants of the severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) have been emerging and circulating in different parts of the world. Millions of vaccine doses have been administered globally, which reduces the morbidity and mortality of coronavirus disease\u20102019 efficiently. Here, we assess the immune responses of individuals after two shots of BBIBP\u2010CorV or CoronaVac inactivated vaccine. We measured neutralizing antibody responses after the second vaccination by using authentic SARS\u2010CoV\u20102 and its viral variants. All the serum samples efficiently neutralized SARS\u2010CoV\u20102 wild\u2010type lineage, in contrast, a part of serum samples failed to neutralize Alpha, Beta, Gamma, Delta, or Eta lineages, and only several serum samples were able to neutralize Omicron lineage virus strains (BA.1 and BA.2) with low neutralization titer. As compared with the neutralization of SARS\u2010CoV\u20102 wild\u2010type lineage, the neutralization of all other SARS\u2010CoV\u20102 variant lineages was significantly lower. Considering that all the SARS\u2010CoV\u20102 mutation viruses challenged the antibody neutralization induced by BBIBP\u2010CorV and CoronaVac, it is necessary to carry out a third booster vaccination to increase the humoral immune response against the SARS\u2010CoV\u20102 mutation viruses.<\/jats:p>","DOI":"10.1002\/jmv.28049","type":"journal-article","created":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T01:34:30Z","timestamp":1659749670000},"page":"6065-6072","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Serosurvey in SARS\u2010CoV\u20102 inactivated vaccine\u2010elicited neutralizing antibodies against authentic SARS\u2010CoV\u20102 and its viral variants"],"prefix":"10.1002","volume":"94","author":[{"given":"Lirong","family":"Zou","sequence":"first","affiliation":[{"name":"Institute of Microbiology Guangdong Provincial Center for Disease Control and Prevention Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Microbiology Guangdong Provincial Center for Disease Control and Prevention Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhonghua","family":"Zheng","sequence":"additional","affiliation":[{"name":"Institute of Microbiology Guangdong Provincial Center for Disease Control and Prevention Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yushan","family":"Jiang","sequence":"additional","affiliation":[{"name":"BSL\u20103 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yushi","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Microbiology Guangdong Provincial Center for Disease Control and Prevention Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shujian","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Microbiology Guangdong Provincial Center for Disease Control and Prevention Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxiang","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute of Microbiology Guangdong Provincial Center for Disease Control and Prevention Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoling","family":"Deng","sequence":"additional","affiliation":[{"name":"Institute of Microbiology Guangdong Provincial Center for Disease Control and Prevention Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfeng","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Microbiology Guangdong Provincial Center for Disease Control and Prevention Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8607-3750","authenticated-orcid":false,"given":"Chenguang","family":"Shen","sequence":"additional","affiliation":[{"name":"BSL\u20103 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baisheng","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Microbiology Guangdong Provincial Center for Disease Control and Prevention Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,15]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"WHO.Coronavirus (COVID\u201019) Dashboard [EB\/OL]. 2022. Accessed July 5 2022.\u00a0https:\/\/covid19.who.int\/"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9030227"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.06.002"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcab171"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-021-00514-9"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2022.01.004"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc2241"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2021.1940305"},{"key":"e_1_2_9_10_1","unstructured":"GingerT JuliaM ManarA et al.Outbreak.info Research Library: A standardized searchable platform to discover and explore COVID\u201019 resources.\u00a02022.\u00a0 Accesse\u00a0July\u00a05 \u00a02022.https:\/\/outbreak.info\/"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2021.10.006"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines10060880"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","unstructured":"WangQ GuoY IketaniS et al.Antibody evasion by SARS\u2010CoV\u20102 omicron subvariants BA.2.12.1 BA.4 & BA.5.Nature. 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