{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T02:36:26Z","timestamp":1773110186664,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Coronavirus disease 2019 (COVID\u201019) can affect people of all age groups and it can occasionally cause life\u2010threatening clinical illnesses in immunologically immature populations, especially in newborns. High red cell distribution width (RDW) values were used as an early prognostic biomarker of some neonatal diseases. We aimed to determine the prognostic value of RDW in severe acute respiratory syndrome\u2010coronavirus\u20102 (SARS\u2010CoV\u20102) infected neonates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Newborns with positive SARS\u2010CoV\u20102<jats:italic>polymerase chain<\/jats:italic>reaction (PCR) test from a nasopharyngeal swab sample, who had refractory fever (&gt;38\u00b0C and lasting more than 24\u2009h during hospitalization), were screened for multisystem inflammatory syndrome in newborns (MIS\u2010N), systemic inflammatory indexes calculated and cardiologic evaluations. Due to troponin levels (high: &gt;45\u2009ng\/L and low: \u226445\u2009ng\/L) patients were grouped.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of the 68 SARS\u2010CoV\u20102 PCR\u2010positive newborns, 26 patients had refractory fever. Comparison of laboratory findings between the high and low\u2010troponin groups showed that RDW and neutrophil\/lymphocyte ratio values were significantly higher in patients with high troponin levels (<jats:italic>p<\/jats:italic>\u2009=\u20090.022 and<jats:italic>p<\/jats:italic>\u2009=\u20090.030, respectively). The cut\u2010off values with optimal sensitivity and specificity were determined as 1.00 for neutrophil\/lymphocyte ratio (<jats:italic>p<\/jats:italic>\u2009=\u20090.205) and 16.6 for RDW (<jats:italic>p<\/jats:italic>\u2009=\u20090.014). None of the patients died.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Neonatal COVID\u201019 generally has a benign prognosis, but can progress to severe disease and cases of MIS\u2010N are rare. RDW could be prognostic in the diagnosis and management of neonates with SARS\u2010CoV\u20102 infection with high troponin levels.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.28050","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T08:19:02Z","timestamp":1659946742000},"page":"5739-5745","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Could red cell distribution width be used for predicting cardiac injury in neonates with COVID\u201019?"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2113-5591","authenticated-orcid":false,"given":"Sarkhan","family":"Elbayiyev","sequence":"first","affiliation":[{"name":"Department of Neonatology Ankara City Hospital University of Health Sciences Ankara Bilkent Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4831-8950","authenticated-orcid":false,"given":"G\u00fcls\u00fcm K.","family":"\u015eim\u015fek","sequence":"additional","affiliation":[{"name":"Department of Neonatology Ankara City Hospital University of Health Sciences Ankara Bilkent Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5914-5325","authenticated-orcid":false,"given":"Burak","family":"Ceran","sequence":"additional","affiliation":[{"name":"Department of Neonatology Ankara City Hospital University of Health Sciences Ankara Bilkent Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0055-8277","authenticated-orcid":false,"given":"Mustafa \u015e.","family":"Ak\u0131n","sequence":"additional","affiliation":[{"name":"Department of Neonatology Ankara City Hospital University of Health Sciences Ankara Bilkent Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3177-9411","authenticated-orcid":false,"given":"H. G\u00f6zde","family":"Kanmaz Kutman","sequence":"additional","affiliation":[{"name":"Department of Neonatology Ankara City Hospital University of Health Sciences Ankara Bilkent Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9307-3003","authenticated-orcid":false,"given":"Fuat E.","family":"Canpolat","sequence":"additional","affiliation":[{"name":"Department of Neonatology Ankara City Hospital University of Health Sciences Ankara Bilkent Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0254073"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-06645-z"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10090618"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.15422"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmab100"},{"issue":"8","key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1097\/PEC.0000000000001319","article-title":"A study of red cell distribution width in neonatal sepsis","volume":"36","author":"Ellahony DM","year":"2020","journal-title":"Pediatr Emerg Care"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-021-00994-w"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0129258"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2019.104267"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/joa3.12442"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1383564"},{"issue":"3","key":"e_1_2_10_13_1","first-page":"160","article-title":"Red cell distribution width and mean platelet volume in patients with irritable bowel syndrome","volume":"9","author":"Aktas G","year":"2014","journal-title":"Prz Gastroenterol"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000002296"},{"issue":"9","key":"e_1_2_10_15_1","first-page":"556","article-title":"Could red cell distribution width be a marker of thyroid cancer?","volume":"27","author":"Aktas G","year":"2017","journal-title":"J Coll Physicians Surg Pak"},{"issue":"1","key":"e_1_2_10_16_1","first-page":"21","article-title":"Prognostic role of red distribution width (RDW) value in gastric cancer","volume":"31","author":"Y\u00fcksel C","year":"2021","journal-title":"J Coll Physicians Surg Pak"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.22058"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0244129"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10020286"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.67.suppl1.20200678"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13102022"},{"issue":"7","key":"e_1_2_10_22_1","first-page":"572","article-title":"Neonatal multisystem inflammatory syndrome (MIS\u2010N) associated with prenatal maternal SARS\u2010CoV\u20102: a case series","volume":"8","author":"Pawar R","year":"2021","journal-title":"Children (Basel, Switzerland)"},{"key":"e_1_2_10_23_1","unstructured":"Centers for Disease Control and Prevention. Information for healthcare providers about multisystem inflammatory syndrome in children (MIS\u2010C). 2020. Accessed March 2022.https:\/\/www.cdc.gov\/mis-c\/hcp\/"},{"key":"e_1_2_10_24_1","unstructured":"American Academy of Pediatrics. Multisystem inflammatory syndrome in children (MIS\u2010C) interim guidance.2020.\u00a0Accessed\u00a0March 2022.https:\/\/services.aap.org\/en\/pages\/2019-novel-coronavirus-covid-19-infections\/clinical-guidance\/multisystem-inflammatory-syndrome-in-childrenmis-c-interim-guidance\/"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(21)00050-X"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2021.06.075"},{"key":"e_1_2_10_27_1","unstructured":"National Institutes of Health (NIH). Coronavirus disease\u00a02019 (COVID\u201019) treatment guidelines.2021. Accessed April 9.https:\/\/www.covid19treatmentguidelines.nih.gov\/"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.938044"},{"issue":"2","key":"e_1_2_10_29_1","first-page":"e13078","article-title":"Prognosis of COVID\u201019: red cell distribution width, platelet distribution width, and C\u2010reactive protein","volume":"13","author":"Bommenahalli Gowda S","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26797"},{"issue":"9","key":"e_1_2_10_31_1","first-page":"e17837","article-title":"SARS\u2010COV\u20102 infection in children and red blood cell distribution width","volume":"13","author":"Tchidjou Kuekou H","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2020-0272"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28745"},{"key":"e_1_2_10_34_1","first-page":"1","article-title":"Platelet to lymphocyte and neutrophil to lymphocyte ratios are useful in differentiation of thyroid conditions with normal and increased uptake","volume":"35","author":"Af\u015fin H","year":"2021","journal-title":"Ethiop J Health Dev"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.63.12.1065"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.5114\/fmpcr.2020.95311"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2021.1950898"},{"key":"e_1_2_10_38_1","first-page":"425","article-title":"Mean platelet volume increases in type 2 diabetes mellitus independent of HbA1c level","volume":"30","author":"Cakir L","year":"2014","journal-title":"Acta Medica Mediterr"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885066617703348"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.28050","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.28050","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.28050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T11:17:28Z","timestamp":1700911048000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.28050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,16]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1002\/jmv.28050"],"URL":"https:\/\/doi.org\/10.1002\/jmv.28050","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,16]]},"assertion":[{"value":"2022-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}