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Notably, patients with a chronic hepatitis B (CHB) infection are at a 30\u2010fold greater risk of developing hepatocellular carcinoma (HCC), the most common type of primary liver cancer, which is the 3rd deadliest cancer worldwide. Several groups have assessed HBV\u2010related aberrant expression of host\u2010cell long noncoding RNAs (lncRNAs) and how altered expression of specific lncRNAs affects HBV replication and progression to associated disease states. Given the challenges in establishing effective HBV models and analyzing transcriptomic data, this review focuses on lncRNA expression data primarily collected from clinical patient samples and primary human hepatocytes,\u00a0with the subsequent mechanism of action analysis in cell lines or other model systems. 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