{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:20:17Z","timestamp":1790882417615,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T00:00:00Z","timestamp":1660521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this study is to assess the incidence and management of co\u2010infections in hospitalized severe fever with thrombocytopenia syndrome bunyavirus (SFTSV) patients.\u00a0We retrospectively evaluated the microbiological database records of the SFTS patients in the first affiliated hospital of Anhui Medical University from January 1, 2018, to December 1, 2021.\u00a0According to the obtained results, co\u2010infections including pulmonary infection, bloodstream infection, biliary tract infection, urinary tract infection, and abdominal infection were observed in SFTS patients. The incidence rate of fungal infections was found to be high in SFTS patients. Furthermore, we suggest that old age people should be evaluated for the risk of fungal infection. In comparison to the non\u2010infection group, patients in the co\u2010infection group were more likely to get mechanical ventilation, antibacterial treatment, antifungal treatment, and blood product therapy (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), with a significantly longer length of stay (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). In SFTS patients, the most prevalent strains were <jats:italic>Aspergillus fumigatus<\/jats:italic>, <jats:italic>Aspergillus flavus<\/jats:italic>, <jats:italic>Candida<\/jats:italic>, <jats:italic>Klebsiella pneumonia<\/jats:italic>, and <jats:italic>Escherichia coli<\/jats:italic>. In this investigation, 66.2% (106\/160) of patients were given antibiotics, most often Piperacillin\/tazobactam or minocycline. 15.6% (25\/160) of patients were treated with antifungal drugs: 13.1% (21\/160) with voriconazole. Patients with SFTS Associated Pulmonary Aspergillosis (SAPA) received active antifungal treatment, but the mortality rate was still 23.5% (8\/34). Only 6 of the 11 patients with SFTS Associated Candidiasis\u00a0were treated with antifungal drugs with no mortality.\u00a0Due to the high frequency of fungal pulmonary infection in SFTS patients, more standardized fungal detection program should be strengthened.<\/jats:p>","DOI":"10.1002\/jmv.28059","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T02:14:30Z","timestamp":1660097670000},"page":"5916-5921","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Associated microbiota and treatment of severe fever with thrombocytopenia syndrome complicated with infections"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4429-6806","authenticated-orcid":false,"given":"Yin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory The First Affiliated Hospital of Anhui Medical University Hefei Anhui Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory The First Affiliated Hospital of Anhui Medical University Hefei Anhui Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory The First Affiliated Hospital of Anhui Medical University Hefei Anhui Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1010095"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir804"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26544"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30293-7"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268815002678"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.13-0423"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.576640"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13050785"},{"issue":"7","key":"e_1_2_11_10_1","first-page":"1491","article-title":"Invasive pulmonary aspergillosis in patients with severe fever with thrombocytopenia syndrome","volume":"70","author":"Bae S","year":"2020","journal-title":"Clin Infect Dis"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2018.01.005"},{"issue":"4","key":"e_1_2_11_12_1","first-page":"193","article-title":"Guideline for prevention and treatment of sever fever with thrombocytopenia syndrome (2010 version)","volume":"4","author":"Ministry of Health of the People's Republic of China","year":"2011","journal-title":"Chin J Clin Infect Dis"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2021.02.088"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000043"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw326"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/524669"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.01.002"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00626-12"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201906-1185ST"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.28059","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.28059","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.28059","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T12:28:35Z","timestamp":1692620915000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.28059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,15]]},"references-count":18,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1002\/jmv.28059"],"URL":"https:\/\/doi.org\/10.1002\/jmv.28059","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,15]]},"assertion":[{"value":"2022-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}