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Although\u00a0the world enters the third year of the coronavirus disease 2019 pandemic, health and socioeconomic impacts continue to mount, the origin and mechanisms of spill\u2010over of the SARS\u2010CoV\u20102\u00a0into humans\u00a0remain elusive. Therefore, a systematic review of the literature was performed that showcased the integrated information obtained through manual searches, digital databases (PubMed, CINAHL, and MEDLINE) searches, and searches from legitimate publications (1966\u20132022), followed by meta\u2010analysis. Our systematic analysis data proposed three postulated hypotheses concerning the origin of the SARS\u2010CoV\u20102, which include zoonotic origin (Z), laboratory origin (L),\u00a0and obscure origin (O). Despite the fact that the zoonotic origin for SARS\u2010CoV\u20102 has not been conclusively identified to date, our data suggest a zoonotic origin, in contrast to some alternative concepts, including the probability of a laboratory incident or leak. Our data exhibit\u00a0that zoonotic origin (Z) has higher evidence\u2010based support as compared to laboratory origin (L). Importantly, based on all the studies included, we generated the forest plot with 95% confidence intervals (CIs) of the risk ratio estimates. Our meta\u2010analysis further supports the zoonotic origin of SARS\/SARS\u2010CoV\u20102 in the included studies.<\/jats:p>","DOI":"10.1002\/jmv.28060","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T22:59:40Z","timestamp":1660085980000},"page":"5766-5779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Tracing the origin of Severe acute respiratory syndrome coronavirus\u20102 (SARS\u2010CoV\u20102): A systematic review and narrative synthesis"],"prefix":"10.1002","volume":"94","author":[{"given":"Nagendra","family":"Thakur","sequence":"first","affiliation":[{"name":"Department of Microbiology, School of Life Sciences Sikkim University Tadong \u00a0Gangtok India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayak","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Life Sciences Sikkim University Tadong \u00a0Gangtok India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swatantra","family":"Kumar","sequence":"additional","affiliation":[{"name":"Centre for Advanced Research (CFAR), Faculty of Medicine King George's Medical University (KGMU) Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vimal K.","family":"Maurya","sequence":"additional","affiliation":[{"name":"Centre for Advanced Research (CFAR), Faculty of Medicine King George's Medical University (KGMU) Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuldeep","family":"Dhama","sequence":"additional","affiliation":[{"name":"Division of Pathology ICAR\u2010Indian Veterinary Research Institute Izatnagar, Bareilly India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janusz T.","family":"Paweska","sequence":"additional","affiliation":[{"name":"Centre for Emerging Zoonotic and Parasitic Diseases National Institute for Communicable Diseases of the National Health Laboratory Service  PB X4 Sandringham\u2010Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed S.","family":"Abdel\u2010Moneim","sequence":"additional","affiliation":[{"name":"Department of Microbiology, College of Medicine Taif University Al\u2010Taif Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amita","family":"Jain","sequence":"additional","affiliation":[{"name":"Centre for Advanced Research (CFAR), Faculty of Medicine King George's Medical University (KGMU) Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil K.","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Centre for Advanced Research (CFAR), Faculty of Medicine King George's Medical University (KGMU) Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bipin","family":"Puri","sequence":"additional","affiliation":[{"name":"Centre for Advanced Research (CFAR), Faculty of Medicine King George's Medical University (KGMU) Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2856-4185","authenticated-orcid":false,"given":"Shailendra K.","family":"Saxena","sequence":"additional","affiliation":[{"name":"Centre for Advanced Research (CFAR), Faculty of Medicine King George's Medical University (KGMU) Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,7]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization (WHO). 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