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The final pathological diagnosis was determined by the most severe pathological grade among the cervical biopsy, endocervical curettage, and conization. Univariate and multivariate logistic regression analyses were used to investigate the association between multiple HPV infections and cervical lesions, adjusting for age, HPV genotype, gravidity and parity. In total, 33.3% (<jats:italic>n<\/jats:italic>\u2009=\u20092076) of the study population was infected with multiple HPV genotypes. Multiple HPV infections were more prevalent in patients younger than 25 years and older than 55 years, with the rate of multiple HPV infections at 52.8% and 44.3%, respectively. HPV16\\52\\18\\58 are the most common HPV genotypes and usually appear as a single infection. Compared to single HR\u2010HPV infection, multiple HR\u2010HPV infections do not increase the risk of HSIL+, while single HR\u2010HPV coinfected with LR\u2010HPV seems to reduce the risk of HSIL+ (odds ratio\u2009=\u20090.515, confidence interval: 0.370\u20130.719, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Multiple HR\u2010HPV infections cannot be risk\u2010stratified for triage of HR\u2010HPV\u2010positive women.<\/jats:p>","DOI":"10.1002\/jmv.28062","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T05:31:20Z","timestamp":1660109480000},"page":"6028-6036","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Prevalence of multiple human papillomavirus infections and association with cervical lesions among outpatients in Fujian, China: A cross\u2010sectional study"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7706-9976","authenticated-orcid":false,"given":"Yusha","family":"Chen","sequence":"first","affiliation":[{"name":"Cervical Disease Diagnosis and Treatment Health Center, Fujian Maternity and Child Health Hospital, College of Clinical Medical for Obstetrics &amp; Gynecology and Pediatrics Fujian Medical University Fuzhou 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