{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:12:06Z","timestamp":1767831126072,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human adenoviruses (HAdVs) can cause acute respiratory diseases (ARDs) worldwide, and HAdV\u201055 is a reemergent pathogen in recent years. In the study, we investigated an outbreak of ARD at a school due to HAdV\u201055 in Beijing, China, during the early outbreak of coronavirus disease 2019 (COVID\u201019). The epidemic prevention team was dispatched to the school to collect epidemiologic data and nasopharyngeal samples. Then, real\u2010time reverse transcription polymerase chain reaction (PCR) and multiplex PCR assays were used to detect severe acute respiratory syndrome coronavirus 2 and other respiratory pathogens, respectively. One representative HAdV\u201055 isolate was selected and submitted for whole\u2010genome sequencing using a MiSeq system and the whole\u2010genome phylogenetic tree was conducted based on the maximum likelihood method. The outbreak lasted from January 27 to February 6, 2020, and 108 students developed fever, among whom 60 (55.56%) cases were diagnosed with HAdV\u201055 infection in the laboratory using real\u2010time PCR and 56 cases were hospitalized. All the confirmed cases had\u00a0a fever and 11 cases (18.33%) presented with a fever above 39\u00b0C. Other main clinical symptoms included sore throat (43.33%) and headache (43.33%). We obtained and assembled the full genome of one isolate, BJ\u2010446, with 34\u2009761 nucleotides in length. HAdV\u201055 isolate BJ\u2010446 was 99.85% identical to strain QS\u2010DLL, which was the first HAdV\u201055 strain in China isolated from an ARD outbreak in Shanxi in 2006. One and four amino acid mutations were observed in the <jats:italic>hexon<\/jats:italic> gene and the coding region of L2 pV 40.1\u2009kDa protein, respectively. We identified the first HAdV\u201055 infection associated with the ARD outbreak in Beijing since the emergence of COVID\u201019. The study suggests that improved surveillance of HAdV is needed, although\u00a0COVID\u201019 is still prevalent in the world.<\/jats:p>","DOI":"10.1002\/jmv.28074","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T02:09:51Z","timestamp":1660874991000},"page":"6111-6115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["An outbreak of acute respiratory disease caused by HAdV\u201055 in Beijing, China, 2020"],"prefix":"10.1002","volume":"94","author":[{"given":"HongBo","family":"Liu","sequence":"first","affiliation":[{"name":"Chinese PLA Center for Disease Control and Prevention Beijing Fengtai District China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingfeng","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Disease Control and Prevention of Central Theater Command Beijing Shijingshan District 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