{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:53:21Z","timestamp":1791831201943,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic hepatitis B virus (HBV) infection is an important public health problem. <jats:italic>Polygonum perfoliatum<\/jats:italic> L. is a traditional medicinal herb and has been reported to have pharmacological activities such as anti\u2010inflammatory, antibacterial, and antiviral. In this study, the antiviral activities and mechanisms of <jats:italic>Polygonum perfoliatum<\/jats:italic> L. extract against HBV and the effective components were investigated. The results showed that the total extract of <jats:italic>Polygonum perfoliatum<\/jats:italic> L. reduced the levels of HBV e antigen (HBeAg) secretion and the viral covalently closed circular DNA (CCC DNA) formation, but had little or no negative effects on viral capsid assembly and pregenomic RNA packaging. Further fractionation showed that the water extract (WE) fraction exerted comparable anti\u2010HBV activities with the total extract, especially in inhibiting the CCC DNA formation and HBeAg production, indicating that the effective antiviral components are mainly distributed in this fraction. Further study showed that the phenolic acids constituents, protocatechuic acid, and gallic acid, but not ethyl caffeate, which is reported enriched in the WE fraction, showed strong anti\u2010HBV activities in inhibiting viral core DNA synthesis, CCC DNA formation, and HBeAg production. These results suggested that the <jats:italic>Polygonum perfoliatum<\/jats:italic> L. total extract and the related phenolic acids like protocatechuic acid and gallic acid could inhibit HBV replication and also indicated the potential utility of <jats:italic>Polygonum perfoliatum<\/jats:italic> L. and related constituents as sources of novel antivirals against HBV.<\/jats:p>","DOI":"10.1002\/jmv.28087","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T09:16:25Z","timestamp":1661332585000},"page":"5987-5999","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Antiviral activities of <i>Polygonum perfoliatum<\/i> L. extract and related phenolic acid constituents against hepatitis B virus"],"prefix":"10.1002","volume":"94","author":[{"given":"Zhuohang","family":"Chen","sequence":"first","affiliation":[{"name":"School of Public Health (Shenzhen) Shenzhen Campus of Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yuan","sequence":"additional","affiliation":[{"name":"School of Public Health (Shenzhen) Shenzhen Campus of Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Public Health (Shenzhen) Shenzhen Campus of Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhui","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Public Health Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Ministry of Education Southwest Forestry University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Public Health (Shenzhen) Shenzhen Campus of Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siya","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Public Health (Shenzhen) Shenzhen Campus of Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianan","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Public Health (Shenzhen) Shenzhen Campus of Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maohua","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Public Health (Shenzhen) Shenzhen Campus of Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaoya","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Life Sciences and Medicine Zhejiang Sci\u2010Tech University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongsuo","family":"Liang","sequence":"additional","affiliation":[{"name":"College of Life Sciences and Medicine Zhejiang Sci\u2010Tech University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8709-3817","authenticated-orcid":false,"given":"Kuancheng","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Public Health (Shenzhen) Shenzhen Campus of Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"WHO.Global Hepatitis Report; 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