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Diabetes is highly prevalent worldwide, making it frequent comorbidity in patients with dengue fever. Therefore, murine models are needed to understand viral pathogenesis and disease progression. Acquired\u2010induced and inherently diabetic C57BL\/6 and db\/db mice were inoculated with DENV\u20103 via the tail vein. After infection, both the diabetic C57BL\/6 and db\/db mice showed obvious weight loss with clinical manifestations. Quantitative reverse\u2010transcription polymerase chain reaction\u00a0revealed robust and replicable viremia in the two types of diabetic mice. Immunohistochemical detection showed persistent DENV\u20103 infection in the liver. Enzyme\u2010linked immunosorbent assay for cytokine detection revealed that diabetic mice showed more severe inflammatory responses than did nondiabetic mice, and significant histological alterations were observed in diabetic mice. Thus, the diabetic mice were more susceptible to DENV infection than the nondiabetic mice. Taken together, we established two types of immunocompetent diabetic mice for DENV infection, which can be used to further study the mechanisms of dengue pathogenesis in diabetes and to develop antiviral pharmaceuticals and treatments.<\/jats:p>","DOI":"10.1002\/jmv.28088","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T09:21:28Z","timestamp":1661332888000},"page":"5943-5953","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Murine diabetic models for dengue virus infection"],"prefix":"10.1002","volume":"94","author":[{"given":"Xuling","family":"Liu","sequence":"first","affiliation":[{"name":"BSL\u20103 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health Southern Medical University Guangzhou People's Republic of 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