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In the present study, we have evaluated the safety and immunogenicity of a recombinant receptor\u2010binding domain (RBD)\u2010based protein subunit vaccine (Noora vaccine) against COVID\u201019 in adults. This Phase 1 trial is a randomized, double\u2010blind, placebo\u2010controlled study to evaluate the safety and immunogenicity of the recombinant RBD\u2010based protein subunit vaccine (Noora vaccine) against COVID\u201019 in healthy adults volunteers. Eligible participants were included in this study after evaluating their health status and considering the exclusion criteria. They were then randomized into three groups and received three doses of vaccine (80\u2009\u00b5g, 120\u2009\u00b5g, and placebo) on Days 0, 21, and 35. Primary outcomes including solicited, unsolicited, and medically attended adverse events were recorded during this study. Secondary outcomes including the humoral and cellular immunity (including anti\u2010RBD IgG antibody and neutralizing antibody) were measured on Days 0, 21, 28, 35, 42, and 49 by using the ELISA kit and the Virus Neutralization Test (VNT) was performed on day 49. Totally 70 cases were included in this Phase 1 trial and 60 of them completed the study. Safety assessments showed no severe adverse events. Local pain at the vaccine injection site occurred in 80% of the vaccinated volunteers. Induration and redness at the injection site were the other adverse reactions of this vaccine. There was no significant difference between the studied groups regarding adverse reactions. Anti\u2010RBD IgG antibody and neutralizing antibody assessment showed significant seroconversion in comparison to the placebo group (80%, and 100% respectively, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The cellular immunity panel also showed mild to moderate induction of TH1 responses and the VNT showed 78% of seroprotection. The results of this Phase 1 trial showed acceptable safety without serious adverse events and significant seroconversions in the humoral and cellular immunity panel. The dose of 80\u2009\u00b5g is an appropriate dose for injection in the next phases of the trial.<\/jats:p>","DOI":"10.1002\/jmv.28097","type":"journal-article","created":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T10:03:03Z","timestamp":1661594583000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["RETRACTED: Safety and immunogenicity of a recombinant receptor\u2010binding domain\u2010based protein subunit vaccine (Noora vaccine\u2122) against COVID\u201019 in adults: A randomized, double\u2010blind, placebo\u2010controlled, Phase 1 trial"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7015-2638","authenticated-orcid":false,"given":"Jafar","family":"Salimian","sequence":"first","affiliation":[{"name":"Applied Microbiology Research Center, Systems Biology and Poisonings Institute Baqiyatallah University of Medical Sciences Tehran Iran"},{"name":"Chemical Injuries 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