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However, recent reports also suggest the involvement of extrapulmonary tissues in COVID\u201019 pathology. The interplay of both innate and adaptive immune responses is key to COVID\u201019 management. As a result, a robust innate immune response provides the first line of defense, concomitantly, adaptive immunity neutralizes the infection and builds memory for long\u2010term protection. However, dysregulated immunity, both innate and adaptive, can skew towards immunopathology both in acute and chronic cases. Here we have summarized some of the recent findings that provide critical insight into the immunopathology caused by SARS\u2010CoV\u20102, in acute and post\u2010acute cases. Finally, we further discuss some of the immunomodulatory drugs in preclinical and clinical trials for dampening the immunopathology caused by COVID\u201019.<\/jats:p>","DOI":"10.1002\/jmv.28122","type":"journal-article","created":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T04:04:51Z","timestamp":1662177891000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["COVID\u201019 immunopathology: From acute diseases to chronic sequelae"],"prefix":"10.1002","volume":"95","author":[{"given":"Mohd","family":"Arish","sequence":"first","affiliation":[{"name":"Carter Immunology Center University of Virginia Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Qian","sequence":"additional","affiliation":[{"name":"Carter Immunology Center University of Virginia Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harish","family":"Narasimhan","sequence":"additional","affiliation":[{"name":"Carter Immunology Center University of Virginia Charlottesville Virginia USA"},{"name":"Department of Microbiology, Immunology and Cancer Biology University of Virginia Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Sun","sequence":"additional","affiliation":[{"name":"Carter Immunology Center University of Virginia Charlottesville Virginia USA"},{"name":"Department of Microbiology, Immunology and Cancer Biology University of Virginia Charlottesville Virginia USA"},{"name":"Division of Infectious Disease and International Health, Department of Medicine University of Virginia Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,13]]},"reference":[{"key":"e_1_2_14_2_1","unstructured":"COVID\u201019 dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU). 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