{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:59:34Z","timestamp":1791831574482,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100013949","name":"Dana Ilmu Pengetahuan Indonesia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013949","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Maternal hepatitis B\n                    <jats:italic>e<\/jats:italic>\n                    Antigen (HBeAg) positivity poses a risk for hepatitis B virus (HBV) mother\u2010to\u2010child transmission (MTCT). In resource\u2010constrained settings, HBeAg testing is recommended as an alternative to HBV DNA testing to establish antiviral prophylaxis eligibility. Nevertheless, the high prevalence of HBeAg\u2010negative chronic hepatitis B (e\u2010CHB) in many countries should not be overlooked. We studied HBV characteristics and explored the potential MTCT risk among HBeAg\u2010negative\/HBsAg\u2010positive expectant mothers in an area prevalent of e\u2010CHB. Among 1348 pregnant mothers screened for HBV infection, 81 (6.0%) were HBsAg\u2010positive. These women were examined for HBeAg, HBV DNA, and cord blood HBV DNA. Sixteen (19.8%) of the HBsAg\u2010positive mothers were HBeAg\u2010positive, whereas 65 (80.2%) were HBeAg\u2010negative, including eight inactive carriers (HBsAg &lt;100\u2009IU\/ml, HBV DNA\u2009\u2264\u20092000\u2009IU\/ml, and ALT\u2009&lt;\u200940\u2009IU\/L). Of the remaining 57 HBeAg\u2010negative mothers, ten revealed HBV Basal Core Promoter or Precore mutations, with three having high viremia (HBV DNA\u2009&gt;\u2009200\u2009000 IU\/mL), which is associated with a high MTCT risk and therefore qualifies them for antiviral prophylaxis. This pilot study provides a cautionary note to the interpretation of negative HBeAg test results when determining eligibility for MTCT antiviral prophylaxis in situations with limited resources and in regions where e\u2010CHB is prevalent.\n                  <\/jats:p>","DOI":"10.1002\/jmv.28125","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T21:59:30Z","timestamp":1662415170000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A cautionary note to hepatitis B\n                    <i>e<\/i>\n                    antigen (HBeAg)\u2010negative test results in pregnant women in an area prevalent of HBeAg\u2010negative chronic hepatitis B"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8790-4915","authenticated-orcid":false,"given":"Maisuri T.","family":"Chalid","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine and Hasanuddin University Hospital Hasanuddin University  Tamalanrea Makassar South Sulawesi Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1388-4920","authenticated-orcid":false,"family":"Turyadi","sequence":"additional","affiliation":[{"name":"Post Graduate School, Faculty of Medicine Hasanuddin University  Makassar Indonesia"},{"name":"Hepatitis Research Laboratory Eijkman Institute for Molecular Biology  North Jakarta DKI Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8469-932X","authenticated-orcid":false,"given":"Susan I.","family":"Ie","sequence":"additional","affiliation":[{"name":"Hepatitis Research Laboratory Eijkman Institute for Molecular Biology  North Jakarta DKI Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4678-9372","authenticated-orcid":false,"given":"Rizalinda","family":"Sjahril","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine and Hasanuddin University Hospital Hasanuddin University  Makassar South Sulawesi Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5519-3119","authenticated-orcid":false,"given":"Ridha","family":"Wahyuni","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine and Hasanuddin University Hospital Hasanuddin University  Makassar South Sulawesi Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3347-6529","authenticated-orcid":false,"given":"M.","family":"Nasrum Massi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine and Hasanuddin University Hospital Hasanuddin University  Makassar South Sulawesi Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5542-106X","authenticated-orcid":false,"given":"David H.","family":"Muljono","sequence":"additional","affiliation":[{"name":"Hepatitis Research Laboratory Eijkman Institute for Molecular Biology  North Jakarta DKI Jakarta Indonesia"},{"name":"Department of Internal Medicine, Faculty of Medicine Hasanuddin University  Makassar South Sulawesi Indonesia"},{"name":"Faculty of Medicine and Health University of Sydney  New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"World Health Organization. Hepatitis B Key Facts. In. Geneva:World Health Organization;2021."},{"key":"e_1_2_13_3_1","unstructured":"Ministry of Health Republic of Indonesia\u2013National Institute of Health Research and Development (NIHRD).National report on basic health research (RISKESDAS).2013."},{"key":"e_1_2_13_4_1","volume-title":"Guidelines for the prevention, care, and treatment of persons with chronic hepatitis B infection","author":"World Health Organization","year":"2015"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/170.6.1418"},{"key":"e_1_2_13_6_1","volume-title":"Prevention of mother\u2010to\u2010child transmission of hepatitis B virus: guidelines on antiviral prophylaxis in pregnancy","author":"World Health Organization","year":"2020"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-015-9675-4"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.03.021"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29800"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13795"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(17)30295-9"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2893.2002.00304.x"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i24.7644"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1621"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-013-9438-z"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.01.019"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000011406"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30586-7"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000360947"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a021436"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.04.052"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1794"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16097"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.02.075"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2008.01933.x"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23571"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.11.012"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes10030182"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2006.10.008"},{"key":"e_1_2_13_31_1","volume-title":"Global health sector strategy on viral hepatitis 2016\u20102021","author":"World Health Organization","year":"2017"},{"key":"e_1_2_13_32_1","unstructured":"World Health Organization. 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