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However, the role of their combined presence in CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells in patients with chronic hepatitis B virus (HBV) infection, especially those with end\u2010stage liver disease, remains unclear. Blood samples from healthy volunteers and patients with chronic hepatitis B were analyzed via Luminex assay and ELISA to measure plasma cytokine levels. Further, recombinant IL\u201022 was used to stimulate peripheral blood mononuclear cells from healthy volunteers, and the frequency of CD3\n                    <jats:sup>+<\/jats:sup>\n                    CD4\n                    <jats:sup>\u2212<\/jats:sup>\n                    CD7\n                    <jats:sup>+<\/jats:sup>\n                    CD57\n                    <jats:sup>\u2212<\/jats:sup>\n                    T cells and apoptosis rates were investigated via flow cytometry. Patients with end\u2010stage liver disease, particularly those with acute to chronic liver failure, showed decreased CD3\n                    <jats:sup>+<\/jats:sup>\n                    CD4\n                    <jats:sup>\u2212<\/jats:sup>\n                    CD7\n                    <jats:sup>+<\/jats:sup>\n                    CD57\n                    <jats:sup>\u2212<\/jats:sup>\n                    T cell frequency. Furthermore, the prevalence of CD3\n                    <jats:sup>+<\/jats:sup>\n                    CD4\n                    <jats:sup>\u2212<\/jats:sup>\n                    CD7\n                    <jats:sup>+<\/jats:sup>\n                    CD57\n                    <jats:sup>\u2212<\/jats:sup>\n                    T cells was negatively correlated with disease severity, prognosis, and complications (ascites). We also observed that IL\u201022 promoted apoptosis and brought about a decrease in the number of CD3\n                    <jats:sup>+<\/jats:sup>\n                    CD4\n                    <jats:sup>\u2212<\/jats:sup>\n                    CD7\n                    <jats:sup>+<\/jats:sup>\n                    CD57\n                    <jats:sup>\u2212<\/jats:sup>\n                    T cells in a dose\u2010dependent manner. CD3\n                    <jats:sup>+<\/jats:sup>\n                    CD4\n                    <jats:sup>\u2212<\/jats:sup>\n                    CD7\n                    <jats:sup>+<\/jats:sup>\n                    CD57\n                    <jats:sup>\u2212<\/jats:sup>\n                    T cells displayed a B and T lymphocyte attenuator\u00a0(BTLA)\n                    <jats:sup>high<\/jats:sup>\n                    CD25\n                    <jats:sup>high<\/jats:sup>\n                    CD127\n                    <jats:sup>high<\/jats:sup>\n                    immunosuppressive phenotype and showed low interferon\u2010\u03b3, tumor necrosis factor\u2010\u03b1, granzyme A, and perforin expression levels. The present findings will elucidate the pathogenesis of HBV\u2010related end\u2010stage liver disease and aid the identification of novel drug targets.\n                  <\/jats:p>","DOI":"10.1002\/jmv.28129","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T22:58:02Z","timestamp":1662505082000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Decreased frequency of a novel T\u2010lymphocyte subset, CD3\n                    <sup>+<\/sup>\n                    CD4\n                    <sup>\u2212<\/sup>\n                    CD7\n                    <sup>+<\/sup>\n                    CD57\n                    <sup>\u2212<\/sup>\n                    T cells, in hepatitis B virus\u2010related end\u2010stage liver disease might contribute to disease progression"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1157-2501","authenticated-orcid":false,"given":"Xueping","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Fujian Medical University Affiliated First Quanzhou Hospital Quanzhou China"},{"name":"Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Shanghai Institute of Infectious Diseases and Biosecurity, National Medical Center for Infectious Diseases, Huashan Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijuan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Fujian Medical University Affiliated First Quanzhou Hospital Quanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3818-0062","authenticated-orcid":false,"given":"Dawu","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Shanghai Institute of Infectious Diseases and Biosecurity, National Medical Center for Infectious Diseases, Huashan Hospital Fudan University Shanghai China"},{"name":"Department of Liver Center The First Hospital Affiliated to Fujian Medical University Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Bioengineering and Biotechnology, College of Life Sciences and Chemistry Minnan Science and Technology University Quanzhou 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