{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:07:27Z","timestamp":1772982447392,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The maintenance of vaginal microbiota is an important factor to achieve optimum pregnancy outcomes. The study aims to describe the alterations in the composition of vaginal microbiota in pregnant women with coronavirus disease 2019\u00a0(COVID\u201019). This was a prospective case\u2010control study. Vaginal swabs were collected from uninfected pregnant women (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200928) and pregnant women with COVID\u201019 (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200919) during the active phase of infection and within a month after recovering from infection. The vaginal microbiota on the swabs was examined by 16S rRNA gene sequencing. Shannon index indicates that alpha diversity is significantly higher in women with COVID\u201019 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.012). There was a significant decrease in Firmicutes (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.014) with an increase in Bacteroidota (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.018) phyla and a decrease in\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.007) genus in women with COVID\u201019 than those of uninfected pregnant women. The relative abundance of\n                    <jats:italic>L. crispatus, L. iners, L. gasseri<\/jats:italic>\n                    , and\n                    <jats:italic>L. jensenii<\/jats:italic>\n                    were lower in the COVID\u201019 group than in uninfected pregnant women. In subgroup analysis, the amount of\n                    <jats:italic>Ureaplasma<\/jats:italic>\n                    spp. was higher in women with moderate\/severe than those of asymptomatic\/mild disease (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.036). The study revealed that vaginal dysbiosis with low abundance of\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    species occurred in pregnant women infected with severe acute respiratory syndrome coronavirus\u20102.\u00a0These findings may lead to new studies to elucidate the risk of pregnancy adverse outcomes related to COVID\u201019.\n                  <\/jats:p>","DOI":"10.1002\/jmv.28132","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T23:38:30Z","timestamp":1662507510000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Alterations in vaginal microbiota among pregnant women with COVID\u201019"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0774-4294","authenticated-orcid":false,"given":"Ebru","family":"Celik","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine Koc University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3364-514X","authenticated-orcid":false,"given":"Gulin","family":"Ozcan","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, School of Medicine Koc University Istanbul Turkey"},{"name":"Ko\u00e7 University \u0130\u015fBank Research Center for \u0130nfectious Diseases (KUISCID) Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3703-1882","authenticated-orcid":false,"given":"Cansel","family":"Vatansever","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, School of Medicine Koc University Istanbul Turkey"},{"name":"Ko\u00e7 University \u0130\u015fBank Research Center for \u0130nfectious Diseases (KUISCID) Istanbul 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\u0130\u015fBank Research Center for \u0130nfectious Diseases (KUISCID) Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1632-1170","authenticated-orcid":false,"given":"Sebile Guler","family":"Cekic","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine Koc University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1935-9235","authenticated-orcid":false,"given":"Onder","family":"Ergonul","sequence":"additional","affiliation":[{"name":"Ko\u00e7 University \u0130\u015fBank Research Center for \u0130nfectious Diseases (KUISCID) Istanbul Turkey"},{"name":"Department of Infectious Diseases and Clinical Microbiology, School of Medicine Ko\u00e7 University Istanbul 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