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Recently, several SARS\u2010CoV\u20102 variants of concern (VOCs) have emerged and caused numerous cases of reinfection in convalescent COVID\u201019 patients, as well as breakthrough infections in vaccinated individuals. This calls for the development of broad\u2010spectrum antiviral drugs to combat SARS\u2010CoV\u20102 and its VOCs. Pan\u2010coronavirus fusion inhibitors, targeting the conserved heptad repeat 1\u00a0(HR1) in spike protein S2 subunit, can broadly and potently inhibit infection of SARS\u2010CoV\u20102 and its variants, as well as other human coronaviruses. In this review, we summarized the most recent development of pan\u2010coronavirus fusion inhibitors, such as EK1, EK1C4, and EKL1C, and highlighted their potential application in combating current COVID\u201019 infection and reinfection, as well as future emerging coronavirus infectious diseases.<\/jats:p>","DOI":"10.1002\/jmv.28143","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T08:09:06Z","timestamp":1663056546000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Pan\u2010coronavirus fusion inhibitors to combat COVID\u201019 and other emerging coronavirus infectious diseases"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5524-3542","authenticated-orcid":false,"given":"Qiaoshuai","family":"Lan","sequence":"first","affiliation":[{"name":"Key Laboratory of Medical Molecular Virology (MOE\/NHC\/CAMS),\u00a0School of Basic Medical Sciences, 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