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Currently, officially starting from May 2022, an outbreak of monkeypox is ongoing, with 51\u2009000 cases being notified as of September 1, 2022\u201451\u2009408 confirmed, 28 suspected, and 12 fatalities, for a grand total of 51\u2009448 cases. More than 100 countries and territories are affected, from all the six World Health Organization\u00a0regions. There are some striking features, that make this outbreak rather unusual when compared with previous outbreaks, including a shift on average age and the most affected age group, affected sex\/gender, risk factors, clinical course, presentation, and the transmission route. Initially predominantly zoonotic, with an animal\u2010to\u2010human transmission, throughout the last decades, human\u2010to\u2010human transmission has become more and more sustained and effective. In particular, clusters of monkeypox have been described among men having sex with men, some of which have been epidemiologically linked to international travel to nonendemic countries and participation in mass gathering events\/festivals, like the \u201cMaspalomas (Gran Canaria) 2022 pride.\u201d\u00a0This review will specifically focus on the \u201cemerging\u201d transmission route of the monkeypox virus, that is to say, the sexual transmission route, which, although not confirmed yet, seems highly likely in the diffusion of the infectious agent.<\/jats:p>","DOI":"10.1002\/jmv.28145","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:38:18Z","timestamp":1663115898000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Is monkeypox a new, emerging sexually transmitted disease? 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