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Other sarbecoviruses, such as SARS\u2010CoV and SARS\u2010related coronaviruses (SARSr\u2010CoVs), have the potential to cause outbreaks in the future. These facts call for the development of variant\u2010proof SARS\u2010CoV\u20102, pan\u2010sarbecovirus or pan\u2010\u03b2\u2010CoV vaccines. Several novel vaccine platforms have been used to develop vaccines with broad\u2010spectrum neutralizing antibody responses and protective immunity to combat the current SARS\u2010CoV\u20102 and its variants, other sarbecoviruses, as well as other \u03b2\u2010CoVs, in the future. 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