{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:09:01Z","timestamp":1772982541466,"version":"3.50.1"},"reference-count":68,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T00:00:00Z","timestamp":1664841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T00:00:00Z","timestamp":1664841600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32000612"],"award-info":[{"award-number":["32000612"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) is a redox gasotransmitter. It has been shown that H\n                    <jats:sub>2<\/jats:sub>\n                    S has a key role in host antiviral defense by inhibiting interleukin production and S\u2010sulfhydrating Keap1 lead to Nrf2\/ARE pathway activation. However, it is yet unclear whether H\n                    <jats:sub>2<\/jats:sub>\n                    S can play an antiviral role by regulating autophagy. In this study, we found that exogenous H\n                    <jats:sub>2<\/jats:sub>\n                    S decreased the expression of human T\u2010cell leukemia virus type\u20101\u00a0(HTLV\u20101)\u00a0protein and HTLV\u20101 induced autophagosomes accumulation. Transmission electron microscope assays indicated that autophagosomes accumulation decreased after H\n                    <jats:sub>2<\/jats:sub>\n                    S administration. HTLV\u20101\u2010transformed T\u2010cell lines had a high level of CSE (H\n                    <jats:sub>2<\/jats:sub>\n                    S endogenous enzyme) which could be induced in Hela by HTLV\u20101 infection. Immunoblot demonstrated that overexpression of CSE inhibited HTLV\u20101 protein expression and autophagy. And we got the opposite after CSE knockdown. Meanwhile, H\n                    <jats:sub>2<\/jats:sub>\n                    S could not restrain the autophagy when ATG4B had a mutant at its site of 89. In a word, these results suggested that H\n                    <jats:sub>2<\/jats:sub>\n                    S modulated HTLV\u20101 protein expression via ATG4B. Therefore, our findings suggested a new mechanism by which H\n                    <jats:sub>2<\/jats:sub>\n                    S defended against virus infection.\n                  <\/jats:p>","DOI":"10.1002\/jmv.28176","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T23:33:30Z","timestamp":1664235210000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hydrogen sulfide inhibits human T\u2010cell leukemia virus type\u20101 (HTLV\u20101) protein expression via regulation of ATG4B"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4242-2335","authenticated-orcid":false,"given":"Huandi","family":"Liu","sequence":"first","affiliation":[{"name":"Henan Key Laboratory of Immunology and Targeted Drugs, School of Laboratory Medicine Xinxiang Medical University Xinxiang China"},{"name":"Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine Xinxiang Medical, University Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaxiang","family":"Sun","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Immunology and Targeted Drugs, School of Laboratory Medicine Xinxiang Medical University Xinxiang China"},{"name":"Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine Xinxiang Medical, University Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuhong","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine The Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangwei","family":"Duan","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Immunology and Targeted Drugs, School of Laboratory Medicine Xinxiang Medical University Xinxiang China"},{"name":"Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine Xinxiang Medical, University Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuaifeng","family":"Guo","sequence":"additional","affiliation":[{"name":"Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine Xinxiang Medical, University Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine Xinxiang Medical, University Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Wan","sequence":"additional","affiliation":[{"name":"Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine Xinxiang Medical, University Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunduo","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine Xinxiang Medical, University Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoying","family":"Zhi","sequence":"additional","affiliation":[{"name":"Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine Xinxiang Medical, University Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linghui","family":"Yuan","sequence":"additional","affiliation":[{"name":"Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine Xinxiang Medical, University Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Immunology and Targeted Drugs, School of Laboratory Medicine Xinxiang Medical University Xinxiang China"},{"name":"Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine Xinxiang Medical, University Xinxiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0211hyp"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2007.11.003"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2425"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.02.033"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.21.6008"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.010868"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M808026200"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-9528-8_1"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1997.0486"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10050697"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20040243"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.5604\/17322693.1085372"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvp111"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2371"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23363-x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867327666200310120550"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31247"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10163484"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2015.1"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00017.2011"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00212A"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2015.08.007"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000464"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4944"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4645"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvab017"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0241-0"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-092910-154005"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2787"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1569925"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2021.04.003"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M208247200"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.199059"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M212108200"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.046250"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-2-17"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208981"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2012.00388"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00063-09"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.17479.1"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/v10010001"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1991.tb08051.x"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.2428"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2013.552"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02147-12"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.641269"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2018.03.002"},{"issue":"3","key":"e_1_2_11_50_1","first-page":"335","article-title":"Hydrogen sulfide plays an important protective role by influencing autophagy in diseases","volume":"68","author":"Wang J","year":"2019","journal-title":"Physiol Res"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsp2.1181"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201600698R"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku316"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI43238"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M509158200"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2005.11.018"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep41029"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/v10050249"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1740"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15230"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-020-01120-1"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00187.2020"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B2100285"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.24172"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.11.005"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00303-2"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2017.1407887"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2017.1320467"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1709763"}],"updated-by":[{"DOI":"10.1002\/jmv.28803","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000}}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.28176","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.28176","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.28176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:48:30Z","timestamp":1772959710000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.28176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,4]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/jmv.28176"],"URL":"https:\/\/doi.org\/10.1002\/jmv.28176","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,4]]},"assertion":[{"value":"2022-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e28176"}}