{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:48:18Z","timestamp":1786978098236,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Crimean\u2013Congo hemorrhagic fever (CCHF) is an emerging acute viral infection disease, yet its pathophysiology remains largely uncharacterized. Lipid mediators are molecules that play numerous roles in the physiologic and pathophysiologic conditions in certain viral diseases. No previous study evaluated the status of cysteinyl leukotrienes (CYSLT) and 5\u2010lipoxygenase (5\u2010LO) and their relationship with proinflammatory cytokines in CCHF. A total of 90 subjects including 60 CCHF patients and 30 healthy controls were enrolled the study. Serum CYSLT, 5\u2010LO, interleukin\u20106 (IL\u20106), and ferritin levels were determined in the study population. Lower median 5\u2010LO level was determined in patients compared to healthy controls (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0004). Higher ferritin (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and IL\u20106 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) levels in patients than healthy controls. No statistically significant difference was observed between patients and controls in terms of CYSLT levels. No statistically significant differences were observed between mild, moderate, and severe groups in terms of both 5\u2010LO and CYSLT levels. IL\u20106 and ferritin levels were higher in severe group compared mild and moderate groups. In conclusion, changes in 5\u2010LO enzyme and increased inflammation are related with the disease molecular mechanism. Higher inflammatory status contributes to the impaired hemostatic balance in CCHF. Thus, treatment strategies to reduce inflammation may help to prevent bleeding and DIC in patients. IL\u20106 and ferritin can be used to as an additional biomarker in the estmation of the prognosis and diagnosis of the patients.\n                  <\/jats:p>","DOI":"10.1002\/jmv.28199","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T00:48:25Z","timestamp":1665190105000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Leukotriene metabolism and proiflammatory cytokines in Crimean Congo hemorrhagic fever"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9448-3407","authenticated-orcid":false,"given":"K\u00fcbra","family":"Do\u011fan","sequence":"first","affiliation":[{"name":"Department of Biochemistry Sivas Numune Hospital Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serkan","family":"Bolat","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medicine University of Sivas Cumhuriyet Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caner","family":"\u00d6ks\u00fcz","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, School of Medicine University of Sivas Cumhuriyet Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyit Ali","family":"B\u00fcy\u00fcktuna","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, School of Medicine University of Sivas Cumhuriyet Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2003.12.035"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.onehlt.2021.100290"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-020-00815-6"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2022.105244"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuaa066"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00678-1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-014-2238-0"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2021.101092"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10030303"},{"key":"e_1_2_8_11_1","first-page":"88","article-title":"Cellular 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