{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:13:17Z","timestamp":1788455597882,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T00:00:00Z","timestamp":1666224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T00:00:00Z","timestamp":1666224000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Nucleos(t)ide analogs (NAs) cannot completely suppress the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB). This study aimed to identify the risk factors for HCC development in na\u00efve CHB patients treated with current NA. Patients receiving NA (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009905) were recruited retrospectively from the 17 hospitals of the Japanese Red Cross Liver Study Group. All treatment\u2010na\u00efve patients had been receiving current NA continuously for more than 1 year until the end of the follow\u2010up. We analyzed the accuracy of predictive risk score using the area under receiver operating characteristic curve. The albumin\u2013bilirubin (ALBI) score was significantly improved by NA therapy (\u22120.171\u2009\u00b1\u20090.396;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001 at Week 48). A total of 72 (8.0%) patients developed HCC over a median follow\u2010up of 6.2 (1.03\u201315.7) years. An independent predictive factor of HCC development was older age, cirrhosis, lower platelet counts at baseline and ALBI score, and alpha\u2010fetoprotein (AFP) at 1 year after NA therapy according to multivariate analysis. The accuracy was assessed using the PAGE\u2010B, mPAGE\u2010B, aMAP, APA\u2010B, and REAL\u2010B scores that included these factors. Discrimination was generally acceptable for these models. aMAP and REAL\u2010B demonstrated high discrimination with 0.866\/0.862 and 0.833\/0.859 for 3\u2010 and 5\u2010year\u00a0prediction from the status of 1 year after NA therapy, respectively. Baseline age and platelet count, as well as ALBI and AFP one year after NA, were useful for stratifying carcinogenesis risk. The aMAP and REAL\u2010B scores were validated with high accuracy in Japanese CHB patients.\n                  <\/jats:p>","DOI":"10.1002\/jmv.28210","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T05:34:20Z","timestamp":1665552860000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Risk factors for hepatocellular carcinoma at baseline and 1 year after initiation of nucleos(t)ide analog therapy for chronic hepatitis B"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2660-6580","authenticated-orcid":false,"given":"Shun","family":"Kaneko","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan"},{"name":"Department of Gastroenterology and Hepatology Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Kurosaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshie","family":"Mashiba","sequence":"additional","affiliation":[{"name":"Center for Liver\u2010Biliary\u2010Pancreatic Diseases Matsuyama Red Cross Hospital Matsuyama Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Marusawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Japanese Red Cross Osaka Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Japanese Red Cross Otsu Hospital Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Japanese Red Cross Ise Hospital Ise Mie Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Japanese Red Cross Matsue Hospital Matsue Shimane Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Japanese Red Cross Kyoto Daiichi Hospital Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiro","family":"Akahane","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Japanese Red Cross Ishinomaki Hospital Ishinomaki Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Yagisawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Japanese Red Cross Akita Hospital Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsunori","family":"Kusakabe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Japanese Red Cross Nagoya Daini Hospital Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Kobashi","sequence":"additional","affiliation":[{"name":"Department of Hepatology Japanese Red Cross Okayama Hospital Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiko","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Japanese Red Cross Maebashi Hospital Maebashi Gunma Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Japanese Red Cross Medical Center Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikara","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Japanese Red Cross Takamatsu Hospital Takamatsu Kagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Furuta","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Japanese Red Cross Masuda Hospital Masuda Shimane Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuharu","family":"Tamaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hiroshima Red Cross Hospital &amp; 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