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In this systematic review, we aimed to characterize the current face of the disease, with a detailed categorization of mucocutaneous, as well as systemic symptoms of the disease. We searched four main online databases with the keywords \u201c<jats:italic>monkeypox<\/jats:italic>\u201d and \u201c<jats:italic>Orthopoxvirus<\/jats:italic>\u201d. A total of 46 articles were included, with a cumulative number of 1984 confirmed cases. Patients were predominantly men who have sex with men, who were mostly in their 30s, with a history of unprotected sexual contact or international travel. Among mucocutaneous manifestations, anogenital lesions were the most commonly observed, followed by lesions on the limbs, face, trunk, and palms or soles. Among lesion types, vesiculopustular, pustular or pseudo\u2010pustular, vesicular\u2010umbilicated and papular lesions were the most common, mainly presenting asynchronously, with less than 10 lesions on each patient. Almost all patients also reported systemic manifestations, namely fever, lymphadenopathy, fatigue, myalgia, headaches, pharyngitis, and proctitis. Sexual contact is the main pathway of transmission in the current outbreak, with viral shedding in bodily fluids playing a key role. We've compared these idiosyncratic findings of the new outbreak with previous outbreaks. We've also gathered and categorized images from our included studies to make a \u201cclinical atlas\u201d for this \u201cnew\u201d face of monkeypox, which can be of utmost importance for clinicians to be familiarized with, and have a clear picture of monkeypox for their differential diagnoses.<\/jats:p>","DOI":"10.1002\/jmv.28230","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T06:28:10Z","timestamp":1666074490000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["A systematic review and clinical atlas on mucocutaneous presentations of the current monkeypox outbreak: With a comprehensive approach to all dermatologic and nondermatologic aspects of the new and previous monkeypox outbreaks"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5393-0875","authenticated-orcid":false,"given":"Homa","family":"Pourriyahi","sequence":"first","affiliation":[{"name":"Student Research Committee, School of Medicine Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7077-1458","authenticated-orcid":false,"given":"Zeinab","family":"Aryanian","sequence":"additional","affiliation":[{"name":"Autoimmune Bullous Diseases Research Center Tehran University of Medical Sciences Tehran Iran"},{"name":"Department of Dermatology, School of Medicine Babol University of Medical Sciences Babol Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1085-374X","authenticated-orcid":false,"given":"Zeinab Mohseni","family":"Afshar","sequence":"additional","affiliation":[{"name":"Clinical Research Development Center, Imam Reza Hospital Kermanshah University of Medical Sciences  Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1249-4429","authenticated-orcid":false,"given":"Azadeh","family":"Goodarzi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC) Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa559"},{"key":"e_1_2_11_3_1","unstructured":"WHO.Monkeypox:key facts [internet].2022. 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