{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T22:39:22Z","timestamp":1776379162227,"version":"3.51.2"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T00:00:00Z","timestamp":1666915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T00:00:00Z","timestamp":1666915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100013105","name":"Shanghai Rising-Star Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013105","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Despite the high vaccination coverage, potential COVID\u201019 vaccine\u2010induced adverse effects, especially in pregnant women, have not been fully characterized. We examined the association between COVID\u201019 vaccination before conception and maternal thyroid function during early pregnancy. We conducted a retrospective cohort study in Shanghai, China. A total of 6979 pregnant women were included. Vaccine administration was obtained from electronic vaccination records. Serum levels of thyroid hormone were measured by fluorescence and chemiluminescence immunoassays. Among the 6979 included pregnant women, 3470 (49.7%) received at least two doses of an inactivated vaccine. COVID\u201019 vaccination had a statistically significant association with both maternal serum levels of free thyroxine (FT4) and thyroid stimulating hormone (TSH). Compared with unvaccinated pregnant women, the mean FT4 levels were lower in pregnant women who had been vaccinated within 3 months before the date of conception by 0.27\u2009pmol\/L (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u2009\u22120.27, 95% confidence interval [CI], \u22120.42, \u22120.12), and the mean TSH levels were higher by 0.08 mIU\/L (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20090.08, 95% CI, 0.00, 0.15). However, when the interval from vaccination to conception was prolonged to more than 3 months, COVID\u201019 vaccination was not associated with serum FT4 or TSH levels. Moreover, we found that COVID\u201019 vaccination did not significantly associate with maternal hypothyroidism. Our study suggested that vaccination with inactivated COVID\u201019 vaccines before conception might result in a small change in maternal thyroid function, but this did not reach clinically significant levels.\n                  <\/jats:p>","DOI":"10.1002\/jmv.28245","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T02:15:22Z","timestamp":1666232122000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of COVID\u201019 vaccination before conception with maternal thyroid function during early pregnancy: A single\u2010center study in China"],"prefix":"10.1002","volume":"95","author":[{"given":"Yan","family":"Zhao","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Maternal\u2010Fetal Medicine, Shanghai First Maternity and Infant Hospital, School of Medicine Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongbo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Maternal\u2010Fetal Medicine, Shanghai First Maternity and Infant Hospital, School of Medicine Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Maternal\u2010Fetal Medicine, Shanghai First Maternity and Infant Hospital, School of Medicine Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Maternal\u2010Fetal Medicine, Shanghai First Maternity and Infant Hospital, School of Medicine Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Su","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Maternal\u2010Fetal Medicine, Shanghai First Maternity and Infant Hospital, School of Medicine Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yicheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Maternal\u2010Fetal Medicine, Shanghai First Maternity and Infant Hospital, School of Medicine Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Maternal\u2010Fetal Medicine, Shanghai First Maternity and Infant Hospital, School of Medicine Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2755-0489","authenticated-orcid":false,"given":"Liping","family":"Jin","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Maternal\u2010Fetal Medicine, Shanghai First Maternity and Infant Hospital, School of Medicine Tongji University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00592-1"},{"key":"e_1_2_9_3_1","unstructured":"WHO. 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