{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T02:52:43Z","timestamp":1786416763718,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We describe the clinical and demographic characteristics, virological follow\u2010up, and management of five confirmed monkeypox cases from New Delhi, India without any international travel history. The viral load kinetics and viral clearance were estimated in oropharyngeal swabs (OPS), nasopharyngeal swabs (NPS), EDTA blood, serum, urine, and various lesion specimens on every fourth day of follow\u2010up ranging from 5 to 24 post onset day (POD) of illness. All\u00a0five cases presented with mild to moderate\u2010grade intermittent fever, myalgia, and lesions on the genitals, groins, lower limb, trunk, and upper limb. Four cases had non\u2010tender firm lymphadenopathy. No secondary complications or sexually transmitted infections were recorded in these cases except for the presence of viral hepatitis B infection marker hepatitis B virus surface antigen\u00a0(HBsAg) in one case. All the cases were mild and had a good recovery. A\u00a0higher viral load was detected in lesion fluid (POD 9), followed by lesion roof (POD 9), urine (POD 5), lesion base (POD 5), and OPS\/NPS (POD 5). The monkeypox virus\u00a0(MPXV) DNA was detected in clinical samples from 5th to 24th POD. These monkeypox cases without international travel history suggest the underdiagnosed monkeypox infection in the community. This emphasizes the need for active surveillance of MPXV in the high\u2010risk population such as men having sex with men and female sex workers.<\/jats:p>","DOI":"10.1002\/jmv.28249","type":"journal-article","created":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T00:46:50Z","timestamp":1666399610000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Clinical presentation, viral kinetics, and management of human monkeypox cases from New Delhi, India 2022"],"prefix":"10.1002","volume":"95","author":[{"given":"Vineet","family":"Relhan","sequence":"first","affiliation":[{"name":"Maulana Azad Medical College and Lok Nayak Hospital  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rima R.","family":"Sahay","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research\u2010National Institute of Virology  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita M.","family":"Shete","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research\u2010National Institute of Virology  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0861-7166","authenticated-orcid":false,"given":"Pragya D.","family":"Yadav","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research\u2010National Institute of Virology  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijaylaxmi","family":"Sahoo","sequence":"additional","affiliation":[{"name":"Maulana Azad Medical College and Lok Nayak Hospital  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak Y.","family":"Patil","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research\u2010National Institute of Virology  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Maulana Azad Medical College and Lok Nayak Hospital  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kannan Sabarinath","family":"Premachandran Syamaladevi","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research\u2010National Institute of Virology  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalit","family":"Dar","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreelekshmy","family":"Mohandas","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research\u2010National Institute of Virology  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Abraham","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research\u2010National Institute of Virology  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2217\/17460913.2.1.17"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0010141"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032299"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa559"},{"key":"e_1_2_10_6_1","first-page":"1\u20108","article-title":"Epidemiological trends and clinical features of the ongoing monkeypox epidemic: a preliminary pooled data analysis and literature review","author":"Bragazzi NL","year":"2022","journal-title":"J Med Virol"},{"key":"e_1_2_10_7_1","unstructured":"CDC. Monkeypox outbreak global map. 2022.\u00a0Accessed on August 22 2022.\u00a0https:\/\/www.cdc.gov\/poxvirus\/monkeypox\/response\/2022\/world-map.html"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007791"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2207323"},{"key":"e_1_2_10_10_1","unstructured":"World Health Organization. Clinical management and infection prevention and control for monkeypox: interim rapid response guidance 10 June 2022. World Health Organization; 2022."},{"key":"e_1_2_10_11_1","unstructured":"WHO. Monkeypox: experts give virus variants new names. 2022. Accessed on August 22 2022.\u00a0https:\/\/www.who.int\/news\/item\/12-08-2022-monkeypox--experts-give-virus-variants-new-names"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23147866"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2022.08.007"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2006.03.012"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2010.07.012"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00228-6"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00540-0"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00411-X"},{"key":"e_1_2_10_19_1","first-page":"1","article-title":"Retrospective detection of asymptomatic monkeypox virus infection among male sexual health clinic attendees in Belgium","author":"De Baetselier I","year":"2022","journal-title":"Nat Med"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.28249","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.28249","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.28249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:47:08Z","timestamp":1772959628000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.28249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,2]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/jmv.28249"],"URL":"https:\/\/doi.org\/10.1002\/jmv.28249","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-1986039\/v1","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.3.rs-1986039\/v3","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.3.rs-1986039\/v2","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.3.rs-1986039\/v4","asserted-by":"object"}]},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,2]]},"assertion":[{"value":"2022-08-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e28249"}}